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Discovery of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach.
Imai Y, Suzuki R, Matsuda D, Tanaka-Yamamoto N, Ohki Y, Tabata R, Kato S, Sugisaki M, Fujimoto N, Fukunaga T, Kato S, Takahashi T, Kakinuma H. Imai Y, et al. Among authors: kato s. Bioorg Med Chem Lett. 2024 Jan 1;97:129543. doi: 10.1016/j.bmcl.2023.129543. Epub 2023 Nov 6. Bioorg Med Chem Lett. 2024. PMID: 37939863
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.
Imai Y, Suzuki R, Wakasugi D, Matsuda D, Tanaka-Yamamoto N, Ohki Y, Mima M, Endo M, Tabata R, Matsuzawa H, Hasegawa Y, Kato S, Sugisaki M, Miyagawa H, Fujimoto N, Fukunaga T, Kato S, Takahashi T, Kakinuma H. Imai Y, et al. Among authors: kato s. Bioorg Med Chem. 2023 Oct 1;93:117460. doi: 10.1016/j.bmc.2023.117460. Epub 2023 Aug 26. Bioorg Med Chem. 2023. PMID: 37660465
Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.
Nishikawa-Shimono R, Kuwabara M, Fujisaki S, Matsuda D, Endo M, Kamitani M, Futamura A, Nomura Y, Yamaguchi-Sasaki T, Yabuuchi T, Yamaguchi C, Tanaka-Yamamoto N, Satake S, Abe-Sato K, Funayama K, Sakata M, Takahashi S, Hirano K, Fukunaga T, Uozumi Y, Kato S, Tamura Y, Nakamori T, Mima M, Mishima-Tsumagari C, Nozawa D, Imai Y, Asami T. Nishikawa-Shimono R, et al. Among authors: kato s. Bioorg Med Chem Lett. 2024 Jan 1;97:129541. doi: 10.1016/j.bmcl.2023.129541. Epub 2023 Nov 10. Bioorg Med Chem Lett. 2024. PMID: 37952596
Observational Assessment of Changes in Earth's Energy Imbalance Since 2000.
Loeb NG, Ham SH, Allan RP, Thorsen TJ, Meyssignac B, Kato S, Johnson GC, Lyman JM. Loeb NG, et al. Among authors: kato s. Surv Geophys. 2024;45(6):1757-1783. doi: 10.1007/s10712-024-09838-8. Epub 2024 May 7. Surv Geophys. 2024. PMID: 39734427 Free PMC article. Review.
Adjunctive effects of eltrombopag on immunosuppressive therapy for childhood aplastic anemia.
Eguchi K, Ishimura M, Ohga S, Endo S, Saito S, Kamimura S, Keino D, Kato S, Azuma Y, Watanabe A, Inoue A, Higa T, Ozono S, Fujita N, Watanabe K, Takahashi Y; Japan Childhood Aplastic Anemia Study Group. Eguchi K, et al. Among authors: kato s. Int J Hematol. 2024 Dec 27. doi: 10.1007/s12185-024-03903-z. Online ahead of print. Int J Hematol. 2024. PMID: 39730862
7,154 results