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Page 1
Somatic variants as a cause of drug-resistant epilepsy including mesial temporal lobe epilepsy with hippocampal sclerosis.
Carton RJ, Doyle MG, Kearney H, Steward CA, Lench NJ, Rogers A, Heinzen EL, McDonald S, Fay J, Lacey A, Beausang A, Cryan J, Brett F, El-Naggar H, Widdess-Walsh P, Costello D, Kilbride R, Doherty CP, Sweeney KJ, O'Brien DF, Henshall DC, Delanty N, Cavalleri GL, Benson KA. Carton RJ, et al. Among authors: henshall dc. Epilepsia. 2024 May;65(5):1451-1461. doi: 10.1111/epi.17943. Epub 2024 Mar 16. Epilepsia. 2024. PMID: 38491957
Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.
McKiernan RC, Jimenez-Mateos EM, Bray I, Engel T, Brennan GP, Sano T, Michalak Z, Moran C, Delanty N, Farrell M, O'Brien D, Meller R, Simon RP, Stallings RL, Henshall DC. McKiernan RC, et al. Among authors: henshall dc. PLoS One. 2012;7(5):e35921. doi: 10.1371/journal.pone.0035921. Epub 2012 May 15. PLoS One. 2012. PMID: 22615744 Free PMC article.
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.
Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G, Sano T, O'Tuathaigh C, Waddington JL, Prenter S, Delanty N, Farrell MA, O'Brien DF, Conroy RM, Stallings RL, DeFelipe J, Henshall DC. Jimenez-Mateos EM, et al. Among authors: henshall dc. Nat Med. 2012 Jul;18(7):1087-94. doi: 10.1038/nm.2834. Nat Med. 2012. PMID: 22683779 Free PMC article.
CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures.
Engel T, Sanz-Rodgriguez A, Jimenez-Mateos EM, Concannon CG, Jimenez-Pacheco A, Moran C, Mesuret G, Petit E, Delanty N, Farrell MA, O'Brien DF, Prehn JH, Lucas JJ, Henshall DC. Engel T, et al. Among authors: henshall dc. Brain. 2013 Feb;136(Pt 2):577-92. doi: 10.1093/brain/aws337. Epub 2013 Jan 29. Brain. 2013. PMID: 23361066
Involvement of microRNAs in epileptogenesis.
Cattani AA, Allene C, Seifert V, Rosenow F, Henshall DC, Freiman TM. Cattani AA, et al. Among authors: henshall dc. Epilepsia. 2016 Jul;57(7):1015-26. doi: 10.1111/epi.13404. Epub 2016 May 21. Epilepsia. 2016. PMID: 27207608 Free article. Review.
Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.
Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blázquez M, Sanz-Rodriguez A, Olivos-Oré LA, Artalejo AR, Alves M, Letavic M, Miras-Portugal MT, Conroy RM, Delanty N, Farrell MA, O'Brien DF, Bhattacharya A, Engel T, Henshall DC. Jimenez-Pacheco A, et al. Among authors: henshall dc. J Neurosci. 2016 Jun 1;36(22):5920-32. doi: 10.1523/JNEUROSCI.4009-15.2016. J Neurosci. 2016. PMID: 27251615 Free PMC article.
Potent Anti-seizure Effects of Locked Nucleic Acid Antagomirs Targeting miR-134 in Multiple Mouse and Rat Models of Epilepsy.
Reschke CR, Silva LFA, Norwood BA, Senthilkumar K, Morris G, Sanz-Rodriguez A, Conroy RM, Costard L, Neubert V, Bauer S, Farrell MA, O'Brien DF, Delanty N, Schorge S, Pasterkamp RJ, Rosenow F, Henshall DC. Reschke CR, et al. Among authors: henshall dc. Mol Ther Nucleic Acids. 2017 Mar 17;6:45-56. doi: 10.1016/j.omtn.2016.11.002. Epub 2016 Dec 10. Mol Ther Nucleic Acids. 2017. PMID: 28325299 Free PMC article.
238 results