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Mechanism of efficacy of trabectedin against myxoid liposarcoma entails detachment of the FUS-DDIT3 transcription factor from its DNA binding sites.
Craparotta I, Mannarino L, Zadro R, Ballabio S, Marchini S, Pavesi G, Russo M, Renne SL, Meroni M, Ponzo M, Bello E, Sanfilippo R, Casali PG, D'Incalci M, Frapolli R. Craparotta I, et al. J Exp Clin Cancer Res. 2024 Nov 26;43(1):309. doi: 10.1186/s13046-024-03228-z. J Exp Clin Cancer Res. 2024. PMID: 39587691 Free PMC article.
The NIPBL-gene mutation of a Cornelia de Lange Syndrome patient causes deficits in the hepatocyte differentiation of induced Pluripotent Stem Cells via altered chromatin-accessibility.
Foglia M, Guarrera L, Kurosaki M, Cassanmagnago GA, Bolis M, Miduri M, Cereseto A, Umbach A, Craparotta I, Fratelli M, Vallerga A, Paroni G, Zanetti A, Cavallaro AV, Russo L, Garattini E, Terao M. Foglia M, et al. Among authors: craparotta i. Cell Mol Life Sci. 2024 Oct 25;81(1):439. doi: 10.1007/s00018-024-05481-z. Cell Mol Life Sci. 2024. PMID: 39453535 Free PMC article.
Onvansertib treatment overcomes olaparib resistance in high-grade ovarian carcinomas.
Chiappa M, Decio A, Guarrera L, Mengoli I, Karki A, Yemane D, Ghilardi C, Scanziani E, Canesi S, Barbera MC, Craparotta I, Bolis M, Fruscio R, Grasselli C, Ceruti T, Zucchetti M, Patterson JC, Lu RA, Yaffe MB, Ridinger M, Damia G, Guffanti F. Chiappa M, et al. Among authors: craparotta i. Cell Death Dis. 2024 Jul 22;15(7):521. doi: 10.1038/s41419-024-06894-1. Cell Death Dis. 2024. PMID: 39039067 Free PMC article.
Combinatorial strategies targeting NEAT1 and AURKA as new potential therapeutic options for multiple myeloma.
Puccio N, Manzotti G, Mereu E, Torricelli F, Ronchetti D, Cumerlato M, Craparotta I, Di Rito L, Bolis M, Traini V, Manicardi V, Fragliasso V, Torrente Y, Amodio N, Bolli N, Taiana E, Ciarrocchi A, Piva R, Neri A. Puccio N, et al. Among authors: craparotta i. Haematologica. 2024 Dec 1;109(12):4040-4055. doi: 10.3324/haematol.2024.285470. Haematologica. 2024. PMID: 38988264 Free PMC article.
SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA.
Germani S, Van Ho AT, Cherubini A, Varone E, Chernorudskiy A, Renna GM, Fumagalli S, Gobbi M, Lucchetti J, Bolis M, Guarrera L, Craparotta I, Rastelli G, Piccoli G, de Napoli C, Nogara L, Poggio E, Brini M, Cattaneo A, Bachi A, Simmen T, Calì T, Quijano-Roy S, Boncompagni S, Blaauw B, Ferreiro A, Zito E. Germani S, et al. Among authors: craparotta i. Cell Rep Med. 2024 Mar 19;5(3):101439. doi: 10.1016/j.xcrm.2024.101439. Epub 2024 Feb 22. Cell Rep Med. 2024. PMID: 38402623 Free PMC article.
Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy.
Salamone A, Terrone G, Di Sapia R, Balosso S, Ravizza T, Beltrame L, Craparotta I, Mannarino L, Cominesi SR, Rizzi M, Pauletti A, Marchini S, Porcu L, Zimmer TS, Aronica E, During M, Abrahams B, Kondo S, Nishi T, Vezzani A. Salamone A, et al. Among authors: craparotta i. Neurobiol Dis. 2022 Oct 15;173:105835. doi: 10.1016/j.nbd.2022.105835. Epub 2022 Aug 3. Neurobiol Dis. 2022. PMID: 35932989 Free article.
Corrigendum to "Mechanisms of responsiveness to and resistance against trabectedin in murine models of human myxoid liposarcoma" [Genomics Volume 113, Issue 5, September 2021, Pages 3439-3448].
Mannarino L, Craparotta I, Ballabio S, Frapolli R, Meroni M, Bello E, Panini N, Callari M, Sanfilippo R, Casali PG, Barisella M, Fabbroni C, Marchini S, D'Incalci M. Mannarino L, et al. Among authors: craparotta i. Genomics. 2022 Jan;114(1):473. doi: 10.1016/j.ygeno.2021.09.005. Epub 2021 Sep 10. Genomics. 2022. PMID: 34535324 Free article. No abstract available.
31 results