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Molecular engineering of a theranostic molecule that detects Aβ plaques, inhibits Iowa and Dutch mutation Aβ self-aggregation and promotes lysosomal biogenesis for Alzheimer's disease.
Iyaswamy A, Wang X, Zhang H, Vasudevan K, Wankhar D, Lu K, Krishnamoorthi S, Guan XJ, Su CF, Liu J, Kan Y, Jaganathan R, Deng Z, Li HW, Wong MS, Li M. Iyaswamy A, et al. Among authors: guan xj. J Mater Chem B. 2024 Aug 7;12(31):7543-7556. doi: 10.1039/d4tb00479e. J Mater Chem B. 2024. PMID: 38978513
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease.
Iyaswamy A, Thakur A, Guan XJ, Krishnamoorthi S, Fung TY, Lu K, Gaurav I, Yang Z, Su CF, Lau KF, Zhang K, Ng RC, Lian Q, Cheung KH, Ye K, Chen HJ, Li M. Iyaswamy A, et al. Among authors: guan xj. Signal Transduct Target Ther. 2023 Oct 23;8(1):404. doi: 10.1038/s41392-023-01657-4. Signal Transduct Target Ther. 2023. PMID: 37867176 Free PMC article.
PPARɑ Ligand Caudatin Improves Cognitive Functions and Mitigates Alzheimer's Disease Defects By Inducing Autophagy in Mice Models.
Krishnamoorthi S, Iyaswamy A, Sreenivasmurthy SG, Thakur A, Vasudevan K, Kumar G, Guan XJ, Lu K, Gaurav I, Su CF, Zhu Z, Liu J, Kan Y, Jayaraman S, Deng Z, Chua KK, Cheung KH, Yang Z, Song JX, Li M. Krishnamoorthi S, et al. Among authors: guan xj. J Neuroimmune Pharmacol. 2023 Sep;18(3):509-528. doi: 10.1007/s11481-023-10083-w. Epub 2023 Sep 8. J Neuroimmune Pharmacol. 2023. PMID: 37682502
Bromo-protopine, a novel protopine derivative, alleviates tau pathology by activating chaperone-mediated autophagy for Alzheimer's disease therapy.
Sreenivasmurthy SG, Iyaswamy A, Krishnamoorthi S, Reddi RN, Kammala AK, Vasudevan K, Senapati S, Zhu Z, Su CF, Liu J, Guan XJ, Chua KK, Cheung KH, Chen H, Zhang HJ, Zhang Y, Song JX, Kumar Durairajan SS, Li M. Sreenivasmurthy SG, et al. Among authors: guan xj. Front Mol Biosci. 2022 Oct 26;9:1030534. doi: 10.3389/fmolb.2022.1030534. eCollection 2022. Front Mol Biosci. 2022. PMID: 36387280 Free PMC article.
72 results