Jiang Y - Search Results

1

It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs.

Jiang Y, Deane CM, Morris GM, O'Brien EP. Jiang Y, et al. PLoS Comput Biol. 2024 Mar 12;20(3):e1011901. doi: 10.1371/journal.pcbi.1011901. eCollection 2024 Mar. PLoS Comput Biol. 2024. PMID: 38470915 Free PMC article.

2

Is Posttranslational Folding More Efficient Than Refolding from a Denatured State: A Computational Study.

Vu QV, Nissley DA, Jiang Y, O'Brien EP, Li MS. Vu QV, et al. Among authors: jiang y. J Phys Chem B. 2023 Jun 1;127(21):4761-4774. doi: 10.1021/acs.jpcb.3c01694. Epub 2023 May 18. J Phys Chem B. 2023. PMID: 37200608 Free PMC article.

3

Non-covalent Lasso Entanglements in Folded Proteins: Prevalence, Functional Implications, and Evolutionary Significance.

Rana V, Sitarik I, Petucci J, Jiang Y, Song H, O'Brien EP. Rana V, et al. Among authors: jiang y. J Mol Biol. 2024 Mar 15;436(6):168459. doi: 10.1016/j.jmb.2024.168459. Epub 2024 Jan 30. J Mol Biol. 2024. PMID: 38296158 Free PMC article.

4

Mechanical Forces Have a Range of Effects on the Rate of Ribosome Catalyzed Peptidyl Transfer Depending on Direction.

Jiang Y, O'Brien EP. Jiang Y, et al. J Phys Chem B. 2021 Jul 8;125(26):7128-7136. doi: 10.1021/acs.jpcb.1c02263. Epub 2021 Jun 24. J Phys Chem B. 2021. PMID: 34166592 Free PMC article.

5

Universal protein misfolding intermediates can bypass the proteostasis network and remain soluble and less functional.

Nissley DA, Jiang Y, Trovato F, Sitarik I, Narayan KB, To P, Xia Y, Fried SD, O'Brien EP. Nissley DA, et al. Among authors: jiang y. Nat Commun. 2022 Jun 2;13(1):3081. doi: 10.1038/s41467-022-30548-5. Nat Commun. 2022. PMID: 35654797 Free PMC article.

6

How synonymous mutations alter enzyme structure and function over long timescales.

Jiang Y, Neti SS, Sitarik I, Pradhan P, To P, Xia Y, Fried SD, Booker SJ, O'Brien EP. Jiang Y, et al. Nat Chem. 2023 Mar;15(3):308-318. doi: 10.1038/s41557-022-01091-z. Epub 2022 Dec 5. Nat Chem. 2023. PMID: 36471044 Free PMC article.

7

How soluble misfolded proteins bypass chaperones at the molecular level.

Halder R, Nissley DA, Sitarik I, Jiang Y, Rao Y, Vu QV, Li MS, Pritchard J, O'Brien EP. Halder R, et al. Among authors: jiang y. Nat Commun. 2023 Jun 21;14(1):3689. doi: 10.1038/s41467-023-38962-z. Nat Commun. 2023. PMID: 37344452 Free PMC article.

8

Synonymous Mutations Can Alter Protein Dimerization Through Localized Interface Misfolding Involving Self-entanglements.

Lan PD, Nissley DA, Sitarik I, Vu QV, Jiang Y, To P, Xia Y, Fried SD, Li MS, O'Brien EP. Lan PD, et al. Among authors: jiang y. J Mol Biol. 2024 Mar 15;436(6):168487. doi: 10.1016/j.jmb.2024.168487. Epub 2024 Feb 9. J Mol Biol. 2024. PMID: 38341172 Free PMC article.

9

Ribosome Elongation Kinetics of Consecutively Charged Residues Are Coupled to Electrostatic Force.

Leininger SE, Rodriguez J, Vu QV, Jiang Y, Li MS, Deutsch C, O'Brien EP. Leininger SE, et al. Among authors: jiang y. Biochemistry. 2021 Nov 2;60(43):3223-3235. doi: 10.1021/acs.biochem.1c00507. Epub 2021 Oct 15. Biochemistry. 2021. PMID: 34652913 Free PMC article.

10

The driving force for co-translational protein folding is weaker in the ribosome vestibule due to greater water ordering.

Vu QV, Jiang Y, Li MS, O'Brien EP. Vu QV, et al. Among authors: jiang y. Chem Sci. 2021 Aug 3;12(35):11851-11857. doi: 10.1039/d1sc01008e. eCollection 2021 Sep 15. Chem Sci. 2021. PMID: 34659725 Free PMC article.

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