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Chemical tools to expand the ligandable proteome: diversity-oriented synthesis-based photoreactive stereoprobes.
Ogasawara D, Konrad DB, Tan ZY, Carey KL, Luo J, Won SJ, Li H, Carter T, DeMeester KE, Njomen E, Schreiber SL, Xavier RJ, Melillo B, Cravatt BF. Ogasawara D, et al. Among authors: cravatt bf. bioRxiv [Preprint]. 2024 Feb 29:2024.02.27.582206. doi: 10.1101/2024.02.27.582206. bioRxiv. 2024. Update in: Cell Chem Biol. 2024 Dec 19;31(12):2138-2155.e32. doi: 10.1016/j.chembiol.2024.10.005 PMID: 38464067 Free PMC article. Updated. Preprint.
Covalent Targeting of Splicing in T Cells.
Scott KA, Kojima H, Ropek N, Warren CD, Zhang TL, Hogg SJ, Webster C, Zhang X, Rahman J, Melillo B, Cravatt BF, Lyu J, Abdel-Wahab O, Vinogradova EV. Scott KA, et al. Among authors: cravatt bf. bioRxiv [Preprint]. 2023 Dec 18:2023.12.18.572199. doi: 10.1101/2023.12.18.572199. bioRxiv. 2023. Update in: Cell Chem Biol. 2024 Nov 22:S2451-9456(24)00445-8. doi: 10.1016/j.chembiol.2024.10.010 PMID: 38187674 Free PMC article. Updated. Preprint.
Expanding the ligandable proteome by paralog hopping with covalent probes.
Zhang Y, Liu Z, Hirschi M, Brodsky O, Johnson E, Won SJ, Nagata A, Petroski MD, Majmudar JD, Niessen S, VanArsdale T, Gilbert AM, Hayward MM, Stewart AE, Nager AR, Melillo B, Cravatt B. Zhang Y, et al. bioRxiv [Preprint]. 2024 Jan 19:2024.01.18.576274. doi: 10.1101/2024.01.18.576274. bioRxiv. 2024. PMID: 38293178 Free PMC article. Preprint.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, MacRae NS, DeMeester KE, Njomen E, Hargis LM, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. Among authors: cravatt bf. bioRxiv [Preprint]. 2024 Mar 21:2024.03.21.586158. doi: 10.1101/2024.03.21.586158. bioRxiv. 2024. Update in: Mol Cell. 2024 Nov 7;84(21):4125-4141.e10. doi: 10.1016/j.molcel.2024.09.024 PMID: 38562719 Free PMC article. Updated. Preprint.
Redirecting the pioneering function of FOXA1 with covalent small molecules.
Won SJ, Zhang Y, Reinhardt CJ, Hargis LM, MacRae NS, DeMeester KE, Njomen E, Remsberg JR, Melillo B, Cravatt BF, Erb MA. Won SJ, et al. Among authors: cravatt bf. Mol Cell. 2024 Nov 7;84(21):4125-4141.e10. doi: 10.1016/j.molcel.2024.09.024. Epub 2024 Oct 15. Mol Cell. 2024. PMID: 39413792
SF3B1 thermostability as an assay for splicing inhibitor interactions.
Amorello AN, Chandrashekar Reddy G, Melillo B, Cravatt BF, Ghosh AK, Jurica MS. Amorello AN, et al. Among authors: cravatt bf. J Biol Chem. 2024 Dec 24:108135. doi: 10.1016/j.jbc.2024.108135. Online ahead of print. J Biol Chem. 2024. PMID: 39725033 Free article.
Covalent targeting of splicing in T cells.
Scott KA, Kojima H, Ropek N, Warren CD, Zhang TL, Hogg SJ, Sanford H, Webster C, Zhang X, Rahman J, Melillo B, Cravatt BF, Lyu J, Abdel-Wahab O, Vinogradova EV. Scott KA, et al. Among authors: cravatt bf. Cell Chem Biol. 2024 Nov 22:S2451-9456(24)00445-8. doi: 10.1016/j.chembiol.2024.10.010. Online ahead of print. Cell Chem Biol. 2024. PMID: 39591969
Dietary control of peripheral adipose storage capacity through membrane lipid remodelling.
Tol MJ, Shimanaka Y, Bedard AH, Sapia J, Cui L, Colaço-Gaspar M, Hofer P, Ferrari A, Qian K, Kennelly JP, Lee SD, Gao Y, Xiao X, Gao J, Mack JJ, Weston TA, Pan C, Lusis AJ, Williams KJ, Su B, Pike DP, Reed A, Milosevich N, Cravatt BF, Arita M, Young SG, Ford DA, Zechner R, Vanni S, Tontonoz P. Tol MJ, et al. Among authors: cravatt bf. bioRxiv [Preprint]. 2024 Oct 29:2024.10.25.620374. doi: 10.1101/2024.10.25.620374. bioRxiv. 2024. PMID: 39554041 Free PMC article. Preprint.
592 results