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The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik JO, Chen YM, Raybuck AL, Billadeau D, Shapiro V, Springer W, Sun J, Boothby MR, Zeng H. Zhu X, et al. Among authors: springer w. bioRxiv [Preprint]. 2024 Mar 12:2024.02.26.582122. doi: 10.1101/2024.02.26.582122. bioRxiv. 2024. Update in: Nat Commun. 2024 Nov 23;15(1):10163. doi: 10.1038/s41467-024-54344-5 PMID: 38463988 Free PMC article. Updated. Preprint.
Rag-GTPase-TFEB/TFE3 axis controls B cell mitochondrial fitness and humoral immunity independent of mTORC1.
Zhu X, Wu Y, Li Y, Zhou X, Watzlawik JO, Chen YM, Raybuck AL, Billadeau D, Shapiro V, Springer W, Sun J, Boothby MR, Zeng H. Zhu X, et al. Among authors: springer w. Res Sq [Preprint]. 2024 Mar 29:rs.3.rs-3957355. doi: 10.21203/rs.3.rs-3957355/v1. Res Sq. 2024. Update in: Nat Commun. 2024 Nov 23;15(1):10163. doi: 10.1038/s41467-024-54344-5 PMID: 38585731 Free PMC article. Updated. Preprint.
NLRP3 inflammasome activation and altered mitophagy are key pathways in inclusion body myositis.
Naddaf E, Nguyen TKO, Watzlawik JO, Gao H, Hou X, Fiesel FC, Mandrekar J, Kokesh E, Harmsen WS, Lanza IR, Springer W, Trushina E. Naddaf E, et al. Among authors: springer w. medRxiv [Preprint]. 2024 Jun 16:2024.06.15.24308845. doi: 10.1101/2024.06.15.24308845. medRxiv. 2024. Update in: J Cachexia Sarcopenia Muscle. 2025 Feb;16(1):e13672. doi: 10.1002/jcsm.13672 PMID: 38947067 Free PMC article. Updated. Preprint.
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease.
HPS3/TIMI55–REVEAL Collaborative Group; Bowman L, Hopewell JC, Chen F, Wallendszus K, Stevens W, Collins R, Wiviott SD, Cannon CP, Braunwald E, Sammons E, Landray MJ. HPS3/TIMI55–REVEAL Collaborative Group, et al. N Engl J Med. 2017 Sep 28;377(13):1217-1227. doi: 10.1056/NEJMoa1706444. Epub 2017 Aug 28. N Engl J Med. 2017. PMID: 28847206 Free article. Clinical Trial.
[No title available]
[No authors listed] [No authors listed] PMID: 39751212
The UFMylation pathway is impaired in Alzheimer's disease.
Yan T, Heckman MG, Craver EC, Liu CC, Rawlinson BD, Wang X, Murray ME, Dickson DW, Ertekin-Taner N, Lou Z, Bu G, Springer W, Fiesel FC. Yan T, et al. Among authors: springer w. Mol Neurodegener. 2024 Dec 18;19(1):97. doi: 10.1186/s13024-024-00784-y. Mol Neurodegener. 2024. PMID: 39696466 Free PMC article.
Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W.
Bustillos BA, Cocker LT, Coban MA, Weber CA, Bredenberg JM, Boneski PK, Siuda J, Slawek J, Puschmann A, Narendra DP, Graff-Radford NR, Wszolek ZK, Dickson DW, Ross OA, Caulfield TR, Springer W, Fiesel FC. Bustillos BA, et al. Among authors: springer w. Cells. 2024 Sep 13;13(18):1540. doi: 10.3390/cells13181540. Cells. 2024. PMID: 39329724 Free PMC article.
197 results