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ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis.
Barisic D, Chin CR, Meydan C, Teater M, Tsialta I, Mlynarczyk C, Chadburn A, Wang X, Sarkozy M, Xia M, Carson SE, Raggiri S, Debek S, Pelzer B, Durmaz C, Deng Q, Lakra P, Rivas M, Steidl C, Scott DW, Weng AP, Mason CE, Green MR, Melnick A. Barisic D, et al. Among authors: wang x. Cancer Cell. 2024 Apr 8;42(4):583-604.e11. doi: 10.1016/j.ccell.2024.02.010. Epub 2024 Mar 7. Cancer Cell. 2024. PMID: 38458187
Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling.
Giambra V, Jenkins CE, Lam SH, Hoofd C, Belmonte M, Wang X, Gusscott S, Gracias D, Weng AP. Giambra V, et al. Among authors: wang x. Blood. 2015 Jun 18;125(25):3917-27. doi: 10.1182/blood-2014-10-609370. Epub 2015 May 1. Blood. 2015. PMID: 25934477 Free PMC article.
CD44 promotes chemoresistance in T-ALL by increased drug efflux.
Hoofd C, Wang X, Lam S, Jenkins C, Wood B, Giambra V, Weng AP. Hoofd C, et al. Among authors: wang x. Exp Hematol. 2016 Mar;44(3):166-71.e17. doi: 10.1016/j.exphem.2015.12.001. Epub 2015 Dec 18. Exp Hematol. 2016. PMID: 26708679 Free article.
Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.
Kusakabe M, Sun AC, Tyshchenko K, Wong R, Nanda A, Shanna C, Gusscott S, Chavez EA, Lorzadeh A, Zhu A, Hill A, Hung S, Brown S, Babaian A, Wang X, Holt RA, Steidl C, Karsan A, Humphries RK, Eaves CJ, Hirst M, Weng AP. Kusakabe M, et al. Among authors: wang x. Nat Commun. 2019 Jul 2;10(1):2913. doi: 10.1038/s41467-019-10510-8. Nat Commun. 2019. PMID: 31266935 Free PMC article.
Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.
Zhang AW, O'Flanagan C, Chavez EA, Lim JLP, Ceglia N, McPherson A, Wiens M, Walters P, Chan T, Hewitson B, Lai D, Mottok A, Sarkozy C, Chong L, Aoki T, Wang X, Weng AP, McAlpine JN, Aparicio S, Steidl C, Campbell KR, Shah SP. Zhang AW, et al. Among authors: wang x. Nat Methods. 2019 Oct;16(10):1007-1015. doi: 10.1038/s41592-019-0529-1. Epub 2019 Sep 9. Nat Methods. 2019. PMID: 31501550 Free PMC article.
Single Cell Phenotypic Profiling of 27 DLBCL Cases Reveals Marked Intertumoral and Intratumoral Heterogeneity.
Nissen MD, Kusakabe M, Wang X, Simkin G, Gracias D, Tyshchenko K, Hill A, Meskas J, Hung S, Chavez EA, Ennishi D, Aoki T, Sarkozy C, Connors JM, Farinha P, Slack GW, Gascoyne RD, Brinkman RR, Scott DW, Steidl C, Weng AP. Nissen MD, et al. Among authors: wang x. Cytometry A. 2020 Jun;97(6):620-629. doi: 10.1002/cyto.a.23919. Epub 2019 Oct 22. Cytometry A. 2020. PMID: 31637838 Free article.
Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma.
Aoki T, Chong LC, Takata K, Milne K, Hav M, Colombo A, Chavez EA, Nissen M, Wang X, Miyata-Takata T, Lam V, Viganò E, Woolcock BW, Telenius A, Li MY, Healy S, Ghesquiere C, Kos D, Goodyear T, Veldman J, Zhang AW, Kim J, Saberi S, Ding J, Farinha P, Weng AP, Savage KJ, Scott DW, Krystal G, Nelson BH, Mottok A, Merchant A, Shah SP, Steidl C. Aoki T, et al. Among authors: wang x. Cancer Discov. 2020 Mar;10(3):406-421. doi: 10.1158/2159-8290.CD-19-0680. Epub 2019 Dec 19. Cancer Discov. 2020. PMID: 31857391
Single-cell profiling reveals a memory B cell-like subtype of follicular lymphoma with increased transformation risk.
Wang X, Nissen M, Gracias D, Kusakabe M, Simkin G, Jiang A, Duns G, Sarkozy C, Hilton L, Chavez EA, Segat GC, Wong R, Kim J, Aoki T, Islam R, May C, Hung S, Tyshchenko K, Brinkman RR, Hirst M, Karsan A, Freeman C, Sehn LH, Morin RD, Roth AJ, Savage KJ, Craig JW, Shah SP, Steidl C, Scott DW, Weng AP. Wang X, et al. Nat Commun. 2022 Nov 9;13(1):6772. doi: 10.1038/s41467-022-34408-0. Nat Commun. 2022. PMID: 36351924 Free PMC article.
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