Ellington AD - Search Results

1

Biosensor and machine learning-aided engineering of an amaryllidaceae enzyme.

d'Oelsnitz S, Diaz DJ, Kim W, Acosta DJ, Dangerfield TL, Schechter MW, Minus MB, Howard JR, Do H, Loy JM, Alper HS, Zhang YJ, Ellington AD. d'Oelsnitz S, et al. Among authors: ellington ad. Nat Commun. 2024 Mar 7;15(1):2084. doi: 10.1038/s41467-024-46356-y. Nat Commun. 2024. PMID: 38453941 Free PMC article.

2

Continuous directed evolution for strain and protein engineering.

d'Oelsnitz S, Ellington A. d'Oelsnitz S, et al. Curr Opin Biotechnol. 2018 Oct;53:158-163. doi: 10.1016/j.copbio.2017.12.020. Epub 2018 Feb 13. Curr Opin Biotechnol. 2018. PMID: 29444489 Review.

3

Custom selenoprotein production enabled by laboratory evolution of recoded bacterial strains.

Thyer R, Shroff R, Klein DR, d'Oelsnitz S, Cotham VC, Byrom M, Brodbelt JS, Ellington AD. Thyer R, et al. Among authors: ellington ad. Nat Biotechnol. 2018 Aug;36(7):624-631. doi: 10.1038/nbt.4154. Epub 2018 Jun 4. Nat Biotechnol. 2018. PMID: 29863724 Free PMC article.

4

Synthetic evolution.

Simon AJ, d'Oelsnitz S, Ellington AD. Simon AJ, et al. Among authors: ellington ad. Nat Biotechnol. 2019 Jul;37(7):730-743. doi: 10.1038/s41587-019-0157-4. Epub 2019 Jun 17. Nat Biotechnol. 2019. PMID: 31209374 Review.

5

Discovery of Novel Gain-of-Function Mutations Guided by Structure-Based Deep Learning.

Shroff R, Cole AW, Diaz DJ, Morrow BR, Donnell I, Annapareddy A, Gollihar J, Ellington AD, Thyer R. Shroff R, et al. Among authors: ellington ad. ACS Synth Biol. 2020 Nov 20;9(11):2927-2935. doi: 10.1021/acssynbio.0c00345. Epub 2020 Oct 16. ACS Synth Biol. 2020. PMID: 33064458

6

Directed Evolution of an Improved Aminoacyl-tRNA Synthetase for Incorporation of L-3,4-Dihydroxyphenylalanine (L-DOPA).

Thyer R, d'Oelsnitz S, Blevins MS, Klein DR, Brodbelt JS, Ellington AD. Thyer R, et al. Among authors: ellington ad. Angew Chem Int Ed Engl. 2021 Jun 25;60(27):14811-14816. doi: 10.1002/anie.202100579. Epub 2021 May 24. Angew Chem Int Ed Engl. 2021. PMID: 33871147 Free PMC article.

7

Learning the local landscape of protein structures with convolutional neural networks.

Kulikova AV, Diaz DJ, Loy JM, Ellington AD, Wilke CO. Kulikova AV, et al. Among authors: ellington ad. J Biol Phys. 2021 Dec;47(4):435-454. doi: 10.1007/s10867-021-09593-6. Epub 2021 Nov 9. J Biol Phys. 2021. PMID: 34751854 Free PMC article.

8

Improved Bst DNA Polymerase Variants Derived via a Machine Learning Approach.

Paik I, Ngo PHT, Shroff R, Diaz DJ, Maranhao AC, Walker DJF, Bhadra S, Ellington AD. Paik I, et al. Among authors: ellington ad. Biochemistry. 2023 Jan 17;62(2):410-418. doi: 10.1021/acs.biochem.1c00451. Epub 2021 Nov 11. Biochemistry. 2023. PMID: 34762799 Free PMC article.

9

Evolving a Generalist Biosensor for Bicyclic Monoterpenes.

d'Oelsnitz S, Nguyen V, Alper HS, Ellington AD. d'Oelsnitz S, et al. Among authors: ellington ad. ACS Synth Biol. 2022 Jan 21;11(1):265-272. doi: 10.1021/acssynbio.1c00402. Epub 2022 Jan 5. ACS Synth Biol. 2022. PMID: 34985281

10

Machine learning-aided engineering of hydrolases for PET depolymerization.

Lu H, Diaz DJ, Czarnecki NJ, Zhu C, Kim W, Shroff R, Acosta DJ, Alexander BR, Cole HO, Zhang Y, Lynd NA, Ellington AD, Alper HS. Lu H, et al. Among authors: ellington ad. Nature. 2022 Apr;604(7907):662-667. doi: 10.1038/s41586-022-04599-z. Epub 2022 Apr 27. Nature. 2022. PMID: 35478237

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