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Page 1
Deubiquitinases in muscle physiology and disorders.
Olie CS, O'Brien DP, Jones HBL, Liang Z, Damianou A, Sur-Erdem I, Pinto-Fernández A, Raz V, Kessler BM. Olie CS, et al. Among authors: pinto fernandez a. Biochem Soc Trans. 2024 Jun 26;52(3):1085-1098. doi: 10.1042/BST20230562. Biochem Soc Trans. 2024. PMID: 38716888 Free PMC article. Review.
Type I interferon regulation by USP18 is a key vulnerability in cancer.
Jové V, Wheeler H, Lee CW, Healy DR, Levine K, Ralph EC, Yamaguchi M, Jiang ZK, Cabral E, Xu Y, Stock J, Yang B, Giddabasappa A, Loria P, Casimiro-Garcia A, Kessler BM, Pinto-Fernández A, Frattini V, Wes PD, Wang F. Jové V, et al. Among authors: pinto fernandez a. iScience. 2024 Mar 27;27(4):109593. doi: 10.1016/j.isci.2024.109593. eCollection 2024 Apr 19. iScience. 2024. PMID: 38632987 Free PMC article.
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Hamid MHBA, Cespedes PF, Jin C, Chen JL, Gileadi U, Antoun E, Liang Z, Gao F, Teague R, Manoharan N, Maldonado-Perez D, Khalid-Alham N, Cerundolo L, Ciaoca R, Hester SS, Pinto-Fernández A, Draganov SD, Vendrell I, Liu G, Yao X, Kvalvaag A, Dominey-Foy DCC, Nanayakkara C, Kanellakis N, Chen YL, Waugh C, Clark SA, Clark K, Sopp P, Rahman NM, Verrill C, Kessler BM, Ogg G, Fernandes RA, Fisher R, Peng Y, Dustin ML, Dong T. Hamid MHBA, et al. Among authors: pinto fernandez a. Nat Immunol. 2024 May;25(5):834-846. doi: 10.1038/s41590-024-01802-3. Epub 2024 Apr 1. Nat Immunol. 2024. PMID: 38561495 Free PMC article.
Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.
Imhoff RD, Patel R, Safdar MH, Jones HBL, Pinto-Fernandez A, Vendrell I, Chen H, Muli CS, Krabill AD, Kessler BM, Wendt MK, Das C, Flaherty DP. Imhoff RD, et al. Among authors: pinto fernandez a. J Med Chem. 2024 Mar 28;67(6):4496-4524. doi: 10.1021/acs.jmedchem.3c01661. Epub 2024 Mar 15. J Med Chem. 2024. PMID: 38488146
Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex.
Damianou A, Liang Z, Lassen F, Vendrell I, Vere G, Hester S, Charles PD, Pinto-Fernandez A, Santos A, Fischer R, Kessler BM. Damianou A, et al. Among authors: pinto fernandez a. Life Sci Alliance. 2024 Mar 7;7(5):e202302245. doi: 10.26508/lsa.202302245. Print 2024 May. Life Sci Alliance. 2024. PMID: 38453365 Free PMC article.
USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Gan J, Pinto-Fernández A, Flierman D, Akkermans JJLL, O'Brien DP, Greenwood H, Scott HC, Fritz G, Knobeloch KP, Neefjes J, van Dam H, Ovaa H, Ploegh HL, Kessler BM, Geurink PP, Sapmaz A. Gan J, et al. Among authors: pinto fernandez a. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055744 Free PMC article.
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides.
O'Brien DP, Jones HBL, Guenther F, Murphy EJ, England KS, Vendrell I, Anderson M, Brennan PE, Davis JB, Pinto-Fernández A, Turnbull AP, Kessler BM. O'Brien DP, et al. Among authors: pinto fernandez a. Mol Cell Proteomics. 2023 Aug;22(8):100609. doi: 10.1016/j.mcpro.2023.100609. Epub 2023 Jun 28. Mol Cell Proteomics. 2023. PMID: 37385347 Free PMC article.
USP18 is an essential regulator of muscle cell differentiation and maturation.
Olie CS, Pinto-Fernández A, Damianou A, Vendrell I, Mei H, den Hamer B, van der Wal E, de Greef JC, Raz V, Kessler BM. Olie CS, et al. Among authors: pinto fernandez a. Cell Death Dis. 2023 Mar 31;14(3):231. doi: 10.1038/s41419-023-05725-z. Cell Death Dis. 2023. PMID: 37002195 Free PMC article.
32 results