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Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches.
Niarakis A, Ostaszewski M, Mazein A, Kuperstein I, Kutmon M, Gillespie ME, Funahashi A, Acencio ML, Hemedan A, Aichem M, Klein K, Czauderna T, Burtscher F, Yamada TG, Hiki Y, Hiroi NF, Hu F, Pham N, Ehrhart F, Willighagen EL, Valdeolivas A, Dugourd A, Messina F, Esteban-Medina M, Peña-Chilet M, Rian K, Soliman S, Aghamiri SS, Puniya BL, Naldi A, Helikar T, Singh V, Fernández MF, Bermudez V, Tsirvouli E, Montagud A, Noël V, Ponce-de-Leon M, Maier D, Bauch A, Gyori BM, Bachman JA, Luna A, Piñero J, Furlong LI, Balaur I, Rougny A, Jarosz Y, Overall RW, Phair R, Perfetto L, Matthews L, Rex DAB, Orlic-Milacic M, Gomez LCM, De Meulder B, Ravel JM, Jassal B, Satagopam V, Wu G, Golebiewski M, Gawron P, Calzone L, Beckmann JS, Evelo CT, D'Eustachio P, Schreiber F, Saez-Rodriguez J, Dopazo J, Kuiper M, Valencia A, Wolkenhauer O, Kitano H, Barillot E, Auffray C, Balling R, Schneider R; COVID-19 Disease Map Community. Niarakis A, et al. Among authors: auffray c. Front Immunol. 2024 Feb 13;14:1282859. doi: 10.3389/fimmu.2023.1282859. eCollection 2023. Front Immunol. 2024. PMID: 38414974 Free PMC article.
Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.
Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H; Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group. Jevnikar Z, et al. J Allergy Clin Immunol. 2019 Feb;143(2):577-590. doi: 10.1016/j.jaci.2018.05.026. Epub 2018 Jun 11. J Allergy Clin Immunol. 2019. PMID: 29902480 Free article.
Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers.
Brandsma J, Goss VM, Yang X, Bakke PS, Caruso M, Chanez P, Dahlén SE, Fowler SJ, Horvath I, Krug N, Montuschi P, Sanak M, Sandström T, Shaw DE, Chung KF, Singer F, Fleming LJ, Sousa AR, Pandis I, Bansal AT, Sterk PJ, Djukanović R, Postle AD; U-BIOPRED Study Group. Brandsma J, et al. Metabolomics. 2018 Sep 17;14(10):123. doi: 10.1007/s11306-018-1412-2. Metabolomics. 2018. PMID: 30830396 Free PMC article.
IL-17-high asthma with features of a psoriasis immunophenotype.
Östling J, van Geest M, Schofield JPR, Jevnikar Z, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, Sousa AR, Guo Y, Adcock IM, Howarth P, Chung KF, Bigler J, Sterk PJ, Skipp PJ, Djukanović R, Vaarala O; U-BIOPRED Study Group. Östling J, et al. Among authors: auffray c. J Allergy Clin Immunol. 2019 Nov;144(5):1198-1213. doi: 10.1016/j.jaci.2019.03.027. Epub 2019 Apr 15. J Allergy Clin Immunol. 2019. PMID: 30998987 Free article. Clinical Trial.
Treatable traits in the European U-BIOPRED adult asthma cohorts.
Simpson AJ, Hekking PP, Shaw DE, Fleming LJ, Roberts G, Riley JH, Bates S, Sousa AR, Bansal AT, Pandis I, Sun K, Bakke PS, Caruso M, Dahlén B, Dahlén SE, Horvath I, Krug N, Montuschi P, Sandstrom T, Singer F, Adcock IM, Wagers SS, Djukanovic R, Chung KF, Sterk PJ, Fowler SJ; U-BIOPRED Study Group. Simpson AJ, et al. Allergy. 2019 Feb;74(2):406-411. doi: 10.1111/all.13629. Epub 2018 Nov 12. Allergy. 2019. PMID: 30307629 Free PMC article. No abstract available.
Radiomultiomics: quantitative CT clusters of severe asthma associated with multi-omics.
Kermani NZ, Chung KF, Macis G, Santini G, Clemeno FAA, Versi A, Sun K, Abdel-Aziz MI, Andersson LI, Auffray C, Badi Y, Bakke P, Brightling C, Brinkman P, Caruso M, Chanez P, De Meulder B, Djukanovic R, Fabbri L, Fowler SJ, Horvath I, Howarth P, James AJ, Kolmert J, Kraft M, Li CX, Maitland-van der Zee AH, Malerba M, Papi A, Rabe K, Sanak M, Shaw DE, Singh D, Mikus MS, van Den Berge M, Wheelock AM, Wheelock CE, Yasinska V, Guo YK, Wagers S, Barnes PJ, Bush A, Sterk PJ, Dahlen SE, Adcock IM, Siddiqui S, Montuschi P; U-BIOPRED and ATLANTIS Study Groups. Kermani NZ, et al. Among authors: auffray c. Eur Respir J. 2024 Oct 10:2400207. doi: 10.1183/13993003.00207-2024. Online ahead of print. Eur Respir J. 2024. PMID: 39401856
PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research.
Lawlor A, Beyer K, Russell B, Steinbeisser C, Bjartell A, De Meulder B, Omar MI, Hulsen T, Butler J, N'Dow J, Rivas JG, Gandaglia G, Nicoletti R, Sakalis V, Smith EJ, Maass M, Zong J, Fullwood L, Abbott T, Tafreshiha A, Papineni K, Snijder R, Horgan D, Seager S, Evans-Axelsson S, Ribal MJ, Roobol MJ, Van Hemelrijck M; PIONEER Consortium. Lawlor A, et al. Nat Rev Urol. 2024 Sep 9. doi: 10.1038/s41585-024-00925-4. Online ahead of print. Nat Rev Urol. 2024. PMID: 39251785 Review.
Iron Boosts Antitumor Type 1 T-cell Responses and Anti-PD1 Immunotherapy.
Porte S, Audemard-Verger A, Wu C, Durand A, Level T, Giraud L, Lombès A, Germain M, Pierre R, Saintpierre B, Lambert M, Auffray C, Peyssonnaux C, Goldwasser F, Vaulont S, Alves-Guerra MC, Dentin R, Lucas B, Martin B. Porte S, et al. Among authors: auffray c. Cancer Immunol Res. 2024 Sep 3;12(9):1252-1267. doi: 10.1158/2326-6066.CIR-23-0739. Cancer Immunol Res. 2024. PMID: 38912762
Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice.
Durand A, Bonilla N, Level T, Ginestet Z, Lombès A, Guichard V, Germain M, Jacques S, Letourneur F, Do Cruzeiro M, Marchiol C, Renault G, Le Gall M, Charvet C, Le Bon A, Martin B, Auffray C, Lucas B. Durand A, et al. Among authors: auffray c. Nat Commun. 2024 Feb 26;15(1):1718. doi: 10.1038/s41467-024-45984-8. Nat Commun. 2024. PMID: 38409097 Free PMC article.
342 results