Scott DK - Search Results

1

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

Katz LS, Visser EJ, Plitzko KF, Pennings MAM, Cossar PJ, Tse IL, Kaiser M, Brunsveld L, Ottmann C, Scott DK. Katz LS, et al. Among authors: scott dk. bioRxiv [Preprint]. 2024 Nov 17:2024.02.16.580675. doi: 10.1101/2024.02.16.580675. bioRxiv. 2024. PMID: 38405965 Free PMC article. Preprint.

2

NRF2 Dysregulation in Mice Leads to Inadequate Beta-Cell Mass Expansion during Pregnancy and Gestational Diabetes.

Baumel-Alterzon S, Tse I, Heidery F, Garcia-Ocaña A, Scott DK. Baumel-Alterzon S, et al. Among authors: scott dk. bioRxiv [Preprint]. 2023 Aug 28:2023.08.28.555207. doi: 10.1101/2023.08.28.555207. bioRxiv. 2023. PMID: 37693560 Free PMC article. Preprint.

3

NRF2 is required for neonatal mouse beta cell growth by maintaining redox balance and promoting mitochondrial biogenesis and function.

Baumel-Alterzon S, Katz LS, Lambertini L, Tse I, Heidery F, Garcia-Ocaña A, Scott DK. Baumel-Alterzon S, et al. Among authors: scott dk. Diabetologia. 2024 Mar;67(3):547-560. doi: 10.1007/s00125-023-06071-7. Epub 2024 Jan 11. Diabetologia. 2024. PMID: 38206362 Free PMC article.

4

Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells.

Wang P, Wood O, Choleva L, Liu H, Karakose E, Lambertini L, Pillard A, Wu V, Garcia-Ocana A, Scott DK, Kumar K, DeVita RJ, Stewart AF. Wang P, et al. Among authors: scott dk. bioRxiv [Preprint]. 2024 May 17:2024.05.17.594179. doi: 10.1101/2024.05.17.594179. bioRxiv. 2024. PMID: 38798411 Free PMC article. Preprint.

5

Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors.

Karakose E, Wang X, Wang P, Carcamo S, Demircioglu D, Lambertini L, Wood O, Kang R, Lu G, Scott DK, Garcia-Ocaña A, Argmann C, Sebra RP, Hasson D, Stewart AF. Karakose E, et al. Among authors: scott dk. Cell Rep Med. 2024 Dec 17;5(12):101832. doi: 10.1016/j.xcrm.2024.101832. Epub 2024 Dec 2. Cell Rep Med. 2024. PMID: 39626675 Free PMC article.

6

Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms.

Kang RB, Lee J, Varela M, Li Y, Rosselot C, Zhang T, Karakose E, Stewart AF, Scott DK, Garcia-Ocana A, Lu G. Kang RB, et al. Among authors: scott dk. bioRxiv [Preprint]. 2023 Nov 19:2023.11.19.567715. doi: 10.1101/2023.11.19.567715. bioRxiv. 2023. PMID: 38014078 Free PMC article. Preprint.

7

Structure-Function Analysis of p57KIP2 in the Human Pancreatic Beta Cell Reveals a Bipartite Nuclear Localization Signal.

Choleva L, Wang P, Liu H, Wood O, Lambertini L, Scott DK, Karakose E, Stewart AF. Choleva L, et al. Among authors: scott dk. Endocrinology. 2023 Dec 23;165(2):bqad197. doi: 10.1210/endocr/bqad197. Endocrinology. 2023. PMID: 38151968 Free PMC article.

8

Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes.

Katz LS, Brill G, Wang P, Lambertini L, Zhang P, Haldeman JM, Liu H, Newgard CB, Stewart AF, Garcia-Ocaña A, Scott DK. Katz LS, et al. Among authors: scott dk. Mol Metab. 2024 Jan;79:101848. doi: 10.1016/j.molmet.2023.101848. Epub 2023 Nov 30. Mol Metab. 2024. PMID: 38042369 Free PMC article.

9

Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles.

Kang RB, Li Y, Rosselot C, Zhang T, Siddiq M, Rajbhandari P, Stewart AF, Scott DK, Garcia-Ocana A, Lu G. Kang RB, et al. Among authors: scott dk. Genome Med. 2023 May 1;15(1):30. doi: 10.1186/s13073-023-01179-2. Genome Med. 2023. PMID: 37127706 Free PMC article.

10

T3 and glucose increase expression of phosphoenolpyruvate carboxykinase (PCK1) leading to increased β-cell proliferation.

Katz LS, Argmann C, Lambertini L, Scott DK. Katz LS, et al. Among authors: scott dk. Mol Metab. 2022 Dec;66:101646. doi: 10.1016/j.molmet.2022.101646. Epub 2022 Nov 29. Mol Metab. 2022. PMID: 36455788 Free PMC article.

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