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Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity.
Puumala E, Sychantha D, Lach E, Reeves S, Nabeela S, Fogal M, Nigam A, Johnson JW, Aspuru-Guzik A, Shapiro RS, Uppuluri P, Kalyaanamoorthy S, Magolan J, Whitesell L, Robbins N, Wright GD, Cowen LE. Puumala E, et al. Among authors: uppuluri p. Cell Chem Biol. 2024 Apr 18;31(4):760-775.e17. doi: 10.1016/j.chembiol.2024.01.010. Epub 2024 Feb 22. Cell Chem Biol. 2024. PMID: 38402621 Free article.
Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy.
Puumala E, Nabeela S, Thornburg CC, Grkovic T, Uppuluri P, Whitesell L, O'Keefe BR, Robbins N, Cowen LE. Puumala E, et al. Among authors: uppuluri p. Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0119424. doi: 10.1128/aac.01194-24. Epub 2024 Sep 26. Antimicrob Agents Chemother. 2024. PMID: 39324798 Free PMC article.
Host immune response against fungal biofilms.
Mannan M, Nabeela S, Mishra R, Uppuluri P. Mannan M, et al. Among authors: uppuluri p. Curr Opin Microbiol. 2024 Oct;81:102520. doi: 10.1016/j.mib.2024.102520. Epub 2024 Aug 9. Curr Opin Microbiol. 2024. PMID: 39126962 Free article. Review.
55 results