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Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.
Joseph-Mathurin N, Feldman RL, Lu R, Shirzadi Z, Toomer C, Saint Clair JR, Ma Y, McKay NS, Strain JF, Kilgore C, Friedrichsen KA, Chen CD, Gordon BA, Chen G, Hornbeck RC, Massoumzadeh P, McCullough AA, Wang Q, Li Y, Wang G, Keefe SJ, Schultz SA, Cruchaga C, Preboske GM, Jack CR Jr, Llibre-Guerra JJ, Allegri RF, Ances BM, Berman SB, Brooks WS, Cash DM, Day GS, Fox NC, Fulham M, Ghetti B, Johnson KA, Jucker M, Klunk WE, la Fougère C, Levin J, Niimi Y, Oh H, Perrin RJ, Reischl G, Ringman JM, Saykin AJ, Schofield PR, Su Y, Supnet-Bell C, Vöglein J, Yakushev I, Brickman AM, Morris JC, McDade E, Xiong C, Bateman RJ, Chhatwal JP, Benzinger TLS; Dominantly Inherited Alzheimer Network. Joseph-Mathurin N, et al. Among authors: su y. Alzheimers Dement. 2024 Apr;20(4):2680-2697. doi: 10.1002/alz.13729. Epub 2024 Feb 21. Alzheimers Dement. 2024. PMID: 38380882 Free PMC article.
Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease.
Aguillon D, Langella S, Chen Y, Sanchez JS, Su Y, Vila-Castelar C, Vasquez D, Zetterberg H, Hansson O, Dage JL, Janelidze S, Chen K, Fox-Fuller JT, Aduen P, Martinez JE, Garcia G, Baena A, Guzman C, Johnson KA, Sperling RA, Blennow K, Reiman EM, Lopera F, Quiroz YT. Aguillon D, et al. Among authors: su y. Alzheimers Dement. 2023 Jun;19(6):2585-2594. doi: 10.1002/alz.12906. Epub 2022 Dec 26. Alzheimers Dement. 2023. PMID: 36571821 Free PMC article.
Longitudinal head-to-head comparison of 11C-PiB and 18F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer's disease.
Chen CD, McCullough A, Gordon B, Joseph-Mathurin N, Flores S, McKay NS, Hobbs DA, Hornbeck R, Fagan AM, Cruchaga C, Goate AM, Perrin RJ, Wang G, Li Y, Shi X, Xiong C, Pontecorvo MJ, Klein G, Su Y, Klunk WE, Jack C, Koeppe R, Snider BJ, Berman SB, Roberson ED, Brosch J, Surti G, Jiménez-Velázquez IZ, Galasko D, Honig LS, Brooks WS, Clarnette R, Wallon D, Dubois B, Pariente J, Pasquier F, Sanchez-Valle R, Shcherbinin S, Higgins I, Tunali I, Masters CL, van Dyck CH, Masellis M, Hsiung R, Gauthier S, Salloway S, Clifford DB, Mills S, Supnet-Bell C, McDade E, Bateman RJ, Benzinger TLS; DIAN-TU Study Team. Chen CD, et al. Among authors: su y. Eur J Nucl Med Mol Imaging. 2023 Jul;50(9):2669-2682. doi: 10.1007/s00259-023-06209-0. Epub 2023 Apr 5. Eur J Nucl Med Mol Imaging. 2023. PMID: 37017737 Free PMC article. Clinical Trial.
Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease.
Vila-Castelar C, Chen Y, Langella S, Lopera F, Zetterberg H, Hansson O, Dage JL, Janelidzde S, Su Y, Chen K, Pluim McDowell C, Martinez JE, Ramirez-Gomez L, Garcia G, Aguillon D, Baena A, Giraldo-Chica M, Protas HD, Ghisays V, Rios-Romenets S, Tariot PN, Blennow K, Reiman EM, Quiroz YT. Vila-Castelar C, et al. Among authors: su y. Alzheimers Dement. 2023 Sep;19(9):4127-4138. doi: 10.1002/alz.13314. Epub 2023 Jun 6. Alzheimers Dement. 2023. PMID: 37279390 Free PMC article.
Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.
Su Y, Protas H, Luo J, Chen K, Alosco ML, Adler CH, Balcer LJ, Bernick C, Au R, Banks SJ, Barr WB, Coleman MJ, Dodick DW, Katz DI, Marek KL, McClean MD, McKee AC, Mez J, Daneshvar DH, Palmisano JN, Peskind ER, Turner RW 2nd, Wethe JV, Rabinovici G, Johnson K, Tripodis Y, Cummings JL, Shenton ME, Stern RA, Reiman EM; DIAGNOSE CTE Research Project Investigators. Su Y, et al. Alzheimers Dement. 2024 Mar;20(3):1827-1838. doi: 10.1002/alz.13602. Epub 2023 Dec 22. Alzheimers Dement. 2024. PMID: 38134231 Free PMC article.
Predicting cognitive decline: Which is more useful, baseline amyloid levels or longitudinal change?
Chen G, McKay NS, Gordon BA, Liu J, Joseph-Mathurin N, Schindler SE, Hassenstab J, Aschenbrenner AJ, Wang Q, Schultz SA, Su Y, LaMontagne PJ, Keefe SJ, Massoumzadeh P, Cruchaga C, Xiong C, Morris JC, Benzinger TLS. Chen G, et al. Among authors: su y. Neuroimage Clin. 2024;41:103551. doi: 10.1016/j.nicl.2023.103551. Epub 2023 Dec 15. Neuroimage Clin. 2024. PMID: 38150745 Free PMC article.
Impact of APOE ε4 and ε2 on plasma neurofilament light chain and cognition in autosomal dominant Alzheimer's disease.
Langella S, Bonta K, Chen Y, Su Y, Vasquez D, Aguillon D, Acosta-Baena N, Baena AY, Garcia-Ospina G, Giraldo-Chica M, Tirado V, Muñoz C, Ríos-Romenets S, Guzman-Martínez C, Pruzin JJ, Ghisays V, Arboleda-Velasquez JF, Kosik KS, Tariot PN, Reiman EM, Lopera F, Quiroz YT. Langella S, et al. Among authors: su y. Alzheimers Res Ther. 2024 Oct 1;16(1):208. doi: 10.1186/s13195-024-01572-y. Alzheimers Res Ther. 2024. PMID: 39354618 Free PMC article.
Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults.
Malek-Ahmadi M, Su Y, Ghisays V, Luo J, Devadas V, Chen Y, Lee W, Protas H, Chen K, Zetterberg H, Blennow K, Caselli RJ, Reiman EM. Malek-Ahmadi M, et al. Among authors: su y. Alzheimers Res Ther. 2023 Apr 10;15(1):74. doi: 10.1186/s13195-023-01221-w. Alzheimers Res Ther. 2023. PMID: 37038190 Free PMC article.
Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project.
Stern RA, Trujillo-Rodriguez D, Tripodis Y, Pulukuri SV, Alosco ML, Adler CH, Balcer LJ, Bernick C, Baucom Z, Marek KL, McClean MD, Johnson KA, McKee AC, Stein TD, Mez J, Palmisano JN, Cummings JL, Shenton ME, Reiman EM; DIAGNOSE CTE Research Project Investigators. Stern RA, et al. Alzheimers Res Ther. 2023 Oct 5;15(1):166. doi: 10.1186/s13195-023-01315-5. Alzheimers Res Ther. 2023. PMID: 37798671 Free PMC article.
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