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Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning.
Monti R, Eick L, Hudjashov G, Läll K, Kanoni S, Wolford BN, Wingfield B, Pain O, Wharrie S, Jermy B, McMahon A, Hartonen T, Heyne H, Mars N, Lambert S; Genes and Health Research Team; Hveem K, Inouye M, van Heel DA, Mägi R, Marttinen P, Ripatti S, Ganna A, Lippert C. Monti R, et al. Among authors: inouye m. Am J Hum Genet. 2024 Jul 11;111(7):1431-1447. doi: 10.1016/j.ajhg.2024.06.003. Epub 2024 Jun 21. Am J Hum Genet. 2024. PMID: 38908374 Free PMC article.
Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice.
Tham YK, Bernardo BC, Claridge B, Yildiz GS, Woon LM, Bond S, Fang H, Ooi JYY, Matsumoto A, Luo J, Tai CMK, Harmawan CA, Kiriazis H, Donner DG, Mellett NA, Abel ED, Khan SA, De Souza DP, Doomun SNE, Liu K, Xiang R, Singh M, Inouye M, Meikle PJ, Weeks KL, Drew BG, Greening DW, McMullen JR. Tham YK, et al. Among authors: inouye m. Nat Cardiovasc Res. 2023 Mar;2(3):268-289. doi: 10.1038/s44161-023-00223-z. Epub 2023 Mar 9. Nat Cardiovasc Res. 2023. PMID: 39196021
Harnessing human microbiomes for disease prediction.
Liu Y, Fachrul M, Inouye M, Méric G. Liu Y, et al. Among authors: inouye m. Trends Microbiol. 2024 Jul;32(7):707-719. doi: 10.1016/j.tim.2023.12.004. Epub 2024 Jan 20. Trends Microbiol. 2024. PMID: 38246848 Review.
Lipidomic Risk Score to Enhance Cardiovascular Risk Stratification for Primary Prevention.
Wu J, Giles C, Dakic A, Beyene HB, Huynh K, Wang T, Meikle T, Olshansky G, Salim A, Duong T, Watts GF, Hung J, Hui J, Cadby G, Beilby J, Blangero J, Moses EK, Shaw JE, Magliano DJ, Zhu D, Yang JY, Grieve SM, Wilson A, Chow CK, Vernon ST, Gray MP, Figtree GA, Carrington MJ, Inouye M, Marwick TH, Meikle PJ. Wu J, et al. Among authors: inouye m. J Am Coll Cardiol. 2024 Jul 30;84(5):434-446. doi: 10.1016/j.jacc.2024.04.060. J Am Coll Cardiol. 2024. PMID: 39048275 Free article.
GREENER principles for environmentally sustainable computational science.
Lannelongue L, Aronson HG, Bateman A, Birney E, Caplan T, Juckes M, McEntyre J, Morris AD, Reilly G, Inouye M. Lannelongue L, et al. Among authors: inouye m. Nat Comput Sci. 2023 Jun;3(6):514-521. doi: 10.1038/s43588-023-00461-y. Epub 2023 Jun 26. Nat Comput Sci. 2023. PMID: 38177425 Review.
Misexpression of inactive genes in whole blood is associated with nearby rare structural variants.
Vanderstichele T, Burnham KL, de Klein N, Tardaguila M, Howell B, Walter K, Kundu K, Koeppel J, Lee W, Tokolyi A, Persyn E, Nath AP, Marten J, Petrovski S, Roberts DJ, Di Angelantonio E, Danesh J, Berton A, Platt A, Butterworth AS, Soranzo N, Parts L, Inouye M, Paul DS, Davenport EE. Vanderstichele T, et al. Among authors: inouye m. Am J Hum Genet. 2024 Aug 8;111(8):1524-1543. doi: 10.1016/j.ajhg.2024.06.017. Epub 2024 Jul 24. Am J Hum Genet. 2024. PMID: 39053458 Free PMC article.
Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam.
Silcocks M, Chang X, Thuong Thuong NT, Qin Y, Minh Ha DT, Khac Thai PV, Vijay S, Anh Thu DD, Ngoc Ha VT, Ngoc Nhung H, Huu Lan N, Quynh Nhu NT, Edwards D, Nath A, Pham K, Duc Bang N, Hong Chau TT, Thwaites G, Heemskerk AD, Chuen Khor C, Teo YY, Inouye M, Ong RT-H, Caws M, Holt KE, Dunstan SJ. Silcocks M, et al. Among authors: inouye m. Microbiol Spectr. 2023 Dec 12;11(6):e0256223. doi: 10.1128/spectrum.02562-23. Epub 2023 Nov 16. Microbiol Spectr. 2023. PMID: 37971428 Free PMC article.
1,025 results