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Type-II IFN inhibits SARS-CoV-2 replication in human lung epithelial cells and ex vivo human lung tissues through indoleamine 2,3-dioxygenase-mediated pathways.
Yang D, Chan JF, Yoon C, Luk TY, Shuai H, Hou Y, Huang X, Hu B, Chai Y, Yuen TT, Liu Y, Zhu T, Liu H, Shi J, Wang Y, He Y, Sit KY, Au WK, Zhang AJ, Yuan S, Zhang BZ, Huang YW, Chu H. Yang D, et al. Among authors: zhu t. J Med Virol. 2024 Feb;96(2):e29472. doi: 10.1002/jmv.29472. J Med Virol. 2024. PMID: 38373201
Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron.
Shuai H, Chan JF, Hu B, Chai Y, Yuen TT, Yin F, Huang X, Yoon C, Hu JC, Liu H, Shi J, Liu Y, Zhu T, Zhang J, Hou Y, Wang Y, Lu L, Cai JP, Zhang AJ, Zhou J, Yuan S, Brindley MA, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Shuai H, et al. Among authors: zhu t. Nature. 2022 Mar;603(7902):693-699. doi: 10.1038/s41586-022-04442-5. Epub 2022 Jan 21. Nature. 2022. PMID: 35062016
Targeting ACLY efficiently inhibits SARS-CoV-2 replication.
Yuen TT, Chan JF, Yan B, Shum CC, Liu Y, Shuai H, Hou Y, Huang X, Hu B, Chai Y, Yoon C, Zhu T, Liu H, Shi J, Zhang J, Cai JP, Zhang AJ, Zhou J, Yin F, Yuan S, Zhang BZ, Chu H. Yuen TT, et al. Among authors: zhu t. Int J Biol Sci. 2022 Jul 11;18(12):4714-4730. doi: 10.7150/ijbs.72709. eCollection 2022. Int J Biol Sci. 2022. PMID: 35874959 Free PMC article.
Virological features and pathogenicity of SARS-CoV-2 Omicron BA.2.
Chan JF, Hu B, Chai Y, Shuai H, Liu H, Shi J, Liu Y, Yoon C, Zhang J, Hu JC, Hou Y, Huang X, Yuen TT, Zhu T, Li W, Cai JP, Luo C, Yip CC, Zhang AJ, Zhou J, Yuan S, Zhang BZ, Huang JD, To KK, Yuen KY, Chu H. Chan JF, et al. Among authors: zhu t. Cell Rep Med. 2022 Sep 20;3(9):100743. doi: 10.1016/j.xcrm.2022.100743. Epub 2022 Aug 29. Cell Rep Med. 2022. PMID: 36084644 Free PMC article.
Altered host protease determinants for SARS-CoV-2 Omicron.
Chan JF, Huang X, Hu B, Chai Y, Shi H, Zhu T, Yuen TT, Liu Y, Liu H, Shi J, Wen L, Shuai H, Hou Y, Yoon C, Cai JP, Zhang AJ, Zhou J, Yin F, Yuan S, Zhang BZ, Brindley MA, Shi ZL, Yuen KY, Chu H. Chan JF, et al. Among authors: zhu t. Sci Adv. 2023 Jan 20;9(3):eadd3867. doi: 10.1126/sciadv.add3867. Epub 2023 Jan 20. Sci Adv. 2023. PMID: 36662861 Free PMC article.
The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA.1, BA.2, and BA.5.
Shuai H, Chan JF, Hu B, Chai Y, Yoon C, Liu H, Liu Y, Shi J, Zhu T, Hu JC, Hu YF, Hou Y, Huang X, Yuen TT, Wang Y, Zhang J, Xia Y, Chen LL, Cai JP, Zhang AJ, Yuan S, Zhou J, Zhang BZ, Huang JD, Yuen KY, To KK, Chu H. Shuai H, et al. Among authors: zhu t. EBioMedicine. 2023 Sep;95:104753. doi: 10.1016/j.ebiom.2023.104753. Epub 2023 Aug 12. EBioMedicine. 2023. PMID: 37579626 Free PMC article.
Divergent trajectory of replication and intrinsic pathogenicity of SARS-CoV-2 Omicron post-BA.2/5 subvariants in the upper and lower respiratory tract.
Hu B, Chan JF, Liu Y, Liu H, Chen YX, Shuai H, Hu YF, Hartnoll M, Chen L, Xia Y, Hu JC, Yuen TT, Yoon C, Hou Y, Huang X, Chai Y, Zhu T, Shi J, Wang Y, He Y, Cai JP, Zhou J, Yuan S, Zhang J, Huang JD, Yuen KY, To KK, Zhang BZ, Chu H. Hu B, et al. Among authors: zhu t. EBioMedicine. 2024 Jan;99:104916. doi: 10.1016/j.ebiom.2023.104916. Epub 2023 Dec 14. EBioMedicine. 2024. PMID: 38101297 Free PMC article.
Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3.
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H. Liu Y, et al. Among authors: zhu t. Nat Commun. 2024 Oct 9;15(1):8728. doi: 10.1038/s41467-024-53033-7. Nat Commun. 2024. PMID: 39379369 Free PMC article.
An orally available Mpro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo.
Chu H, Shuai H, Qiao J, Yoon C, Zhang G, Hou Y, Xia X, Wang L, Deng X, Wang Y, Li Q, Du L, Liu Y, Zhou M, Wong HT, Liu H, Hu B, Chen Y, Fang Z, Xia Z, Chai Y, Shi J, Wang Y, Zhu T, Zhang H, Yuan S, Zhou J, Chan J, Yuen KY, Xu C, Lei J, Yang S. Chu H, et al. Among authors: zhu t. Res Sq [Preprint]. 2024 Nov 21:rs.3.rs-5454588. doi: 10.21203/rs.3.rs-5454588/v1. Res Sq. 2024. PMID: 39606435 Free PMC article. Preprint.
8,357 results