Chan D - Search Results

1

Sperm DNA methylation defects in a new mouse model of the 5,10-methylenetetrahydrofolate reductase 677C>T variant and correction with moderate dose folic acid supplementation.

Martínez Duncker Rebolledo E, Chan D, Christensen KE, Reagan AM, Howell GR, Rozen R, Trasler J. Martínez Duncker Rebolledo E, et al. Among authors: chan d. Mol Hum Reprod. 2024 Mar 28;30(4):gaae008. doi: 10.1093/molehr/gaae008. Mol Hum Reprod. 2024. PMID: 38366926 Free PMC article.

2

Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation.

Aarabi M, Christensen KE, Chan D, Leclerc D, Landry M, Ly L, Rozen R, Trasler J. Aarabi M, et al. Among authors: chan d. Hum Mol Genet. 2018 Apr 1;27(7):1123-1135. doi: 10.1093/hmg/ddy021. Hum Mol Genet. 2018. PMID: 29360980 Free PMC article.

3

Reproductive and epigenetic outcomes associated with aging mouse oocytes.

Lopes FL, Fortier AL, Darricarrère N, Chan D, Arnold DR, Trasler JM. Lopes FL, et al. Among authors: chan d. Hum Mol Genet. 2009 Jun 1;18(11):2032-44. doi: 10.1093/hmg/ddp127. Epub 2009 Mar 17. Hum Mol Genet. 2009. PMID: 19293340

4

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.

Aarabi M, San Gabriel MC, Chan D, Behan NA, Caron M, Pastinen T, Bourque G, MacFarlane AJ, Zini A, Trasler J. Aarabi M, et al. Among authors: chan d. Hum Mol Genet. 2015 Nov 15;24(22):6301-13. doi: 10.1093/hmg/ddv338. Epub 2015 Aug 24. Hum Mol Genet. 2015. PMID: 26307085 Free PMC article.

5

Stability of the human sperm DNA methylome to folic acid fortification and short-term supplementation.

Chan D, McGraw S, Klein K, Wallock LM, Konermann C, Plass C, Chan P, Robaire B, Jacob RA, Greenwood CM, Trasler JM. Chan D, et al. Among authors: chan p. Hum Reprod. 2017 Feb;32(2):272-283. doi: 10.1093/humrep/dew308. Epub 2016 Dec 18. Hum Reprod. 2017. PMID: 27994001 Free PMC article. Clinical Trial.

6

Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterning.

Whidden L, Martel J, Rahimi S, Chaillet JR, Chan D, Trasler JM. Whidden L, et al. Among authors: chan d. Hum Mol Genet. 2016 Nov 1;25(21):4649-4660. doi: 10.1093/hmg/ddw293. Hum Mol Genet. 2016. PMID: 28173052

7

Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation.

Ly L, Chan D, Aarabi M, Landry M, Behan NA, MacFarlane AJ, Trasler J. Ly L, et al. Among authors: chan d. Mol Hum Reprod. 2017 Jul 1;23(7):461-477. doi: 10.1093/molehr/gax029. Mol Hum Reprod. 2017. PMID: 28535307 Free PMC article.

8

Moderate maternal folic acid supplementation ameliorates adverse embryonic and epigenetic outcomes associated with assisted reproduction in a mouse model.

Rahimi S, Martel J, Karahan G, Angle C, Behan NA, Chan D, MacFarlane AJ, Trasler JM. Rahimi S, et al. Among authors: chan d. Hum Reprod. 2019 May 1;34(5):851-862. doi: 10.1093/humrep/dez036. Hum Reprod. 2019. PMID: 30989206 Free PMC article.

9

Transgenerational impact of grand-paternal lifetime exposures to both folic acid deficiency and supplementation on genome-wide DNA methylation in male germ cells.

Chan D, Ly L, Rebolledo EMD, Martel J, Landry M, Scott-Boyer MP, Droit A, Trasler JM. Chan D, et al. Andrology. 2023 Jul;11(5):927-942. doi: 10.1111/andr.13399. Epub 2023 Feb 17. Andrology. 2023. PMID: 36697378 Free article.

10

Higher incidence of embryonic defects in mouse offspring conceived with assisted reproduction from fathers with sperm epimutations.

Karahan G, Martel J, Rahimi S, Farag M, Matias F, MacFarlane AJ, Chan D, Trasler J. Karahan G, et al. Among authors: chan d. Hum Mol Genet. 2023 Dec 12;33(1):48-63. doi: 10.1093/hmg/ddad160. Hum Mol Genet. 2023. PMID: 37740387 Free PMC article.

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