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Proof-of-concept evaluation of next-generation sequencing-based liquid biopsy for non-invasive cancer detection in cats.
Ruiz-Perez CA, Nakashe P, Marshall MA, Marass F, Tang T, McLennan LM, Kroll M, Flesner BK, Gray S, Rafalko JM, Grosu DS, Hicks SC, Tynan JA, Tsui DWY, Flory A, Kruglyak KM. Ruiz-Perez CA, et al. Among authors: flesner bk. Front Vet Sci. 2024 Sep 13;11:1394686. doi: 10.3389/fvets.2024.1394686. eCollection 2024. Front Vet Sci. 2024. PMID: 39346958 Free PMC article.
Clinical validation of a blood-based liquid biopsy test integrating cell-free DNA quantification and next-generation sequencing for cancer screening in dogs.
Flory A, Ruiz-Perez CA, Clavere-Graciette AG, Rafalko JM, O'Kell AL, Flesner BK, McLennan LM, Hicks SC, Nakashe P, Phelps-Dunn A, DiMarzio LR, Warren CD, Cohen TA, Chibuk J, Chorny I, Grosu DS, Tsui DWY, Tynan JA, Kruglyak KM. Flory A, et al. Among authors: flesner bk. J Am Vet Med Assoc. 2024 Feb 7;262(5):665-673. doi: 10.2460/javma.23.10.0564. Print 2024 May 1. J Am Vet Med Assoc. 2024. PMID: 38324993
Next-generation sequencing-based liquid biopsy may be used for detection of residual disease and cancer recurrence monitoring in dogs.
McCleary-Wheeler AL, Fiaux PC, Flesner BK, Ruiz-Perez CA, McLennan LM, Tynan JA, Hicks SC, Rafalko JM, Grosu DS, Chibuk J, O'Kell AL, Cohen TA, Chorny I, Tsui DWY, Kruglyak KM, Flory A. McCleary-Wheeler AL, et al. Among authors: flesner bk. Am J Vet Res. 2023 Dec 28:1-8. doi: 10.2460/ajvr.23.07.0163. Online ahead of print. Am J Vet Res. 2023. PMID: 38150822 Free article.
Safety of TCMCB07, a melanocortin-4 antagonist peptide, in dogs with naturally occurring cachexia.
Axiak-Bechtel SM, Leach SB, Newton-Northup JR, Milner RJ, Fox-Alvarez SA, Fagman LI, Young KA, Tate DJ, Wright ZM, Chretin JD, Allen JW, Yoshimoto SK, Selting KA, Flesner BK, White CR, Mills T, Aherne M, Bergman PJ, Qi L, Gruber KA, Callahan MF. Axiak-Bechtel SM, et al. Among authors: flesner bk. J Vet Intern Med. 2023 Nov-Dec;37(6):2344-2355. doi: 10.1111/jvim.16915. Epub 2023 Oct 28. J Vet Intern Med. 2023. PMID: 37897303 Free PMC article.
Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs.
LeBlanc AK, Mazcko CN, Fan TM, Vail DM, Flesner BK, Bryan JN, Li S, Wang F, Harris S, Vargas JD, Govindharajulu JP, Jaganathan S, Tomaino F, Srivastava AK, Chou TF, Stott GM, Covey JM, Mroczkowski B, Doroshow JH. LeBlanc AK, et al. Among authors: flesner bk. Mol Cancer Ther. 2022 Oct 7;21(10):1510-1523. doi: 10.1158/1535-7163.MCT-22-0167. Mol Cancer Ther. 2022. PMID: 35876604 Free PMC article.
Clinical validation of a next-generation sequencing-based multi-cancer early detection "liquid biopsy" blood test in over 1,000 dogs using an independent testing set: The CANcer Detection in Dogs (CANDiD) study.
Flory A, Kruglyak KM, Tynan JA, McLennan LM, Rafalko JM, Fiaux PC, Hernandez GE, Marass F, Nakashe P, Ruiz-Perez CA, Fath DM, Jennings T, Motalli-Pepio R, Wotrang K, McCleary-Wheeler AL, Lana S, Phillips B, Flesner BK, Leibman NF, LaDue T, Tripp CD, Coomber BL, Woods JP, Miller M, Aiken SW, Wolf-Ringwall A, Borgatti A, Kraska K, Thomson CB, Kosanovich Cahalane A, Murray RL, Kisseberth WC, Camps-Palau MA, Floch F, Beaudu-Lange C, Klajer-Peres A, Keravel O, Fribourg-Blanc LA, Mazetier PC, Marco A, McLeod MB, Portillo E, Clark TS, Judd S, Feinberg CK, Benitez M, Runyan C, Hackett L, Lafey S, Richardson D, Vineyard S, Tefend Campbell M, Dharajiya N, Jensen TJ, van den Boom D, Diaz LA Jr, Grosu DS, Polk A, Marsal K, Hicks SC, Lytle KM, Holtvoigt L, Chibuk J, Chorny I, Tsui DWY. Flory A, et al. Among authors: flesner bk. PLoS One. 2022 Apr 26;17(4):e0266623. doi: 10.1371/journal.pone.0266623. eCollection 2022. PLoS One. 2022. PMID: 35471999 Free PMC article.
27 results