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A single-cell time-lapse of mouse prenatal development from gastrula to birth.
Qiu C, Martin BK, Welsh IC, Daza RM, Le TM, Huang X, Nichols EK, Taylor ML, Fulton O, O'Day DR, Gomes AR, Ilcisin S, Srivatsan S, Deng X, Disteche CM, Noble WS, Hamazaki N, Moens CB, Kimelman D, Cao J, Schier AF, Spielmann M, Murray SA, Trapnell C, Shendure J. Qiu C, et al. Among authors: srivatsan s. Nature. 2024 Feb;626(8001):1084-1093. doi: 10.1038/s41586-024-07069-w. Epub 2024 Feb 14. Nature. 2024. PMID: 38355799 Free PMC article.
Predicting cellular responses to complex perturbations in high-throughput screens.
Lotfollahi M, Klimovskaia Susmelj A, De Donno C, Hetzel L, Ji Y, Ibarra IL, Srivatsan SR, Naghipourfar M, Daza RM, Martin B, Shendure J, McFaline-Figueroa JL, Boyeau P, Wolf FA, Yakubova N, Günnemann S, Trapnell C, Lopez-Paz D, Theis FJ. Lotfollahi M, et al. Among authors: srivatsan sr. Mol Syst Biol. 2023 Jun 12;19(6):e11517. doi: 10.15252/msb.202211517. Epub 2023 May 8. Mol Syst Biol. 2023. PMID: 37154091 Free PMC article.
Single-cell, whole-embryo phenotyping of mammalian developmental disorders.
Huang X, Henck J, Qiu C, Sreenivasan VKA, Balachandran S, Amarie OV, Hrabě de Angelis M, Behncke RY, Chan WL, Despang A, Dickel DE, Duran M, Feuchtinger A, Fuchs H, Gailus-Durner V, Haag N, Hägerling R, Hansmeier N, Hennig F, Marshall C, Rajderkar S, Ringel A, Robson M, Saunders LM, da Silva-Buttkus P, Spielmann N, Srivatsan SR, Ulferts S, Wittler L, Zhu Y, Kalscheuer VM, Ibrahim DM, Kurth I, Kornak U, Visel A, Pennacchio LA, Beier DR, Trapnell C, Cao J, Shendure J, Spielmann M. Huang X, et al. Among authors: srivatsan sr. Nature. 2023 Nov;623(7988):772-781. doi: 10.1038/s41586-023-06548-w. Epub 2023 Nov 15. Nature. 2023. PMID: 37968388 Free PMC article.
Embryo-scale reverse genetics at single-cell resolution.
Saunders LM, Srivatsan SR, Duran M, Dorrity MW, Ewing B, Linbo TH, Shendure J, Raible DW, Moens CB, Kimelman D, Trapnell C. Saunders LM, et al. Nature. 2023 Nov;623(7988):782-791. doi: 10.1038/s41586-023-06720-2. Epub 2023 Nov 15. Nature. 2023. PMID: 37968389 Free PMC article.
Multiplex single-cell chemical genomics reveals the kinase dependence of the response to targeted therapy.
McFaline-Figueroa JL, Srivatsan S, Hill AJ, Gasperini M, Jackson DL, Saunders L, Domcke S, Regalado SG, Lazarchuck P, Alvarez S, Monnat RJ Jr, Shendure J, Trapnell C. McFaline-Figueroa JL, et al. Among authors: srivatsan s. Cell Genom. 2024 Feb 14;4(2):100487. doi: 10.1016/j.xgen.2023.100487. Epub 2024 Jan 25. Cell Genom. 2024. PMID: 38278156 Free PMC article.
Retinoic acid induces human gastruloids with posterior embryo-like structures.
Hamazaki N, Yang W, Kubo CA, Qiu C, Martin BK, Garge RK, Regalado SG, Nichols EK, Pendyala S, Bradley N, Fowler DM, Lee C, Daza RM, Srivatsan S, Shendure J. Hamazaki N, et al. Among authors: srivatsan s. Nat Cell Biol. 2024 Oct;26(10):1790-1803. doi: 10.1038/s41556-024-01487-8. Epub 2024 Aug 20. Nat Cell Biol. 2024. PMID: 39164488 Free PMC article.
Single-cell analysis of chromatin and expression reveals age- and sex-associated alterations in the human heart.
Read DF, Booth GT, Daza RM, Jackson DL, Gladden RG, Srivatsan SR, Ewing B, Franks JM, Spurrell CH, Gomes AR, O'Day D, Gogate AA, Martin BK, Larson H, Pfleger C, Starita L, Lin Y, Shendure J, Lin S, Trapnell C. Read DF, et al. Among authors: srivatsan sr. Commun Biol. 2024 Aug 26;7(1):1052. doi: 10.1038/s42003-024-06582-y. Commun Biol. 2024. PMID: 39187646 Free PMC article.
164 results