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Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models.
La Monica S, Vacondio F, Eltayeb K, Lodola A, Volta F, Viglioli M, Ferlenghi F, Galvani F, Galetti M, Bonelli M, Fumarola C, Cavazzoni A, Flammini L, Verzè M, Minari R, Petronini PG, Tiseo M, Mor M, Alfieri R. La Monica S, et al. Among authors: ferlenghi f. Sci Rep. 2024 Mar 18;14(1):6491. doi: 10.1038/s41598-024-57028-8. Sci Rep. 2024. PMID: 38499619 Free PMC article.
Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats.
Barbetti M, Mancabelli L, Vacondio F, Longhi G, Ferlenghi F, Viglioli M, Turroni F, Carnevali L, Mor M, Ventura M, Sgoifo A, Rivara S. Barbetti M, et al. Among authors: ferlenghi f. Prog Neuropsychopharmacol Biol Psychiatry. 2024 Apr 20;131:110963. doi: 10.1016/j.pnpbp.2024.110963. Epub 2024 Feb 12. Prog Neuropsychopharmacol Biol Psychiatry. 2024. PMID: 38354897 Free article.
Expanding the knowledge around antitubercular 5-(2-aminothiazol-4-yl)isoxazole-3-carboxamides: Hit-to-lead optimization and release of a novel antitubercular chemotype via scaffold derivatization.
Girardini M, Ferlenghi F, Annunziato G, Degiacomi G, Papotti B, Marchi C, Sammartino JC, Rasheed SS, Contini A, Pasca MR, Vacondio F, Evans JC, Dick T, Müller R, Costantino G, Pieroni M. Girardini M, et al. Among authors: ferlenghi f. Eur J Med Chem. 2023 Jan 5;245(Pt 2):114916. doi: 10.1016/j.ejmech.2022.114916. Epub 2022 Nov 11. Eur J Med Chem. 2023. PMID: 36399878 Free PMC article.
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph-Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice.
Ferlenghi F, Giorgio C, Incerti M, Guidetti L, Chiodelli P, Rusnati M, Tognolini M, Vacondio F, Mor M, Lodola A. Ferlenghi F, et al. Pharmaceuticals (Basel). 2021 Dec 28;15(1):41. doi: 10.3390/ph15010041. Pharmaceuticals (Basel). 2021. PMID: 35056098 Free PMC article.
25 results