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Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch.
Balzulat A, Zhu WF, Flauaus C, Hernandez-Olmos V, Heering J, Sethumadhavan S, Dubiel M, Frank A, Menge A, Hebchen M, Metzner K, Lu R, Lukowski R, Ruth P, Knapp S, Müller S, Steinhilber D, Hänelt I, Stark H, Proschak E, Schmidtko A. Balzulat A, et al. Among authors: hanelt i. Adv Sci (Weinh). 2024 Apr;11(15):e2307237. doi: 10.1002/advs.202307237. Epub 2024 Feb 13. Adv Sci (Weinh). 2024. PMID: 38350720 Free PMC article.
How RCK domains regulate gating of K+ channels.
Schrecker M, Wunnicke D, Hänelt I. Schrecker M, et al. Among authors: hanelt i. Biol Chem. 2019 Sep 25;400(10):1303-1322. doi: 10.1515/hsz-2019-0153. Biol Chem. 2019. PMID: 31361596 Review.
Molecular Mechanisms for Bacterial Potassium Homeostasis.
Stautz J, Hellmich Y, Fuss MF, Silberberg JM, Devlin JR, Stockbridge RB, Hänelt I. Stautz J, et al. Among authors: hanelt i. J Mol Biol. 2021 Aug 6;433(16):166968. doi: 10.1016/j.jmb.2021.166968. Epub 2021 Mar 30. J Mol Biol. 2021. PMID: 33798529 Free PMC article. Review.
33 results