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Human iPSC-derived pericyte-like cells carrying APP Swedish mutation overproduce beta-amyloid and induce cerebral amyloid angiopathy-like changes.
Wu YC, Lehtonen Š, Trontti K, Kauppinen R, Kettunen P, Leinonen V, Laakso M, Kuusisto J, Hiltunen M, Hovatta I, Freude K, Dhungana H, Koistinaho J, Rolova T. Wu YC, et al. Among authors: rolova t. Fluids Barriers CNS. 2024 Sep 27;21(1):78. doi: 10.1186/s12987-024-00576-y. Fluids Barriers CNS. 2024. PMID: 39334385 Free PMC article.
Genetic contribution to microglial activation in schizophrenia.
Koskuvi M, Pörsti E, Hewitt T, Räsänen N, Wu YC, Trontti K, McQuade A, Kalyanaraman S, Ojansuu I, Vaurio O, Cannon TD, Lönnqvist J, Therman S, Suvisaari J, Kaprio J, Blurton-Jones M, Hovatta I, Lähteenvuo M, Rolova T, Lehtonen Š, Tiihonen J, Koistinaho J. Koskuvi M, et al. Among authors: rolova t. Mol Psychiatry. 2024 Sep;29(9):2622-2633. doi: 10.1038/s41380-024-02529-1. Epub 2024 Mar 22. Mol Psychiatry. 2024. PMID: 38519640 Free PMC article.
SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.
Kettunen P, Lesnikova A, Räsänen N, Ojha R, Palmunen L, Laakso M, Lehtonen Š, Kuusisto J, Pietiläinen O, Saber SH, Joensuu M, Vapalahti OP, Koistinaho J, Rolova T, Balistreri G. Kettunen P, et al. Among authors: rolova t. J Virol. 2023 Apr 27;97(4):e0014423. doi: 10.1128/jvi.00144-23. Epub 2023 Apr 11. J Virol. 2023. PMID: 37039676 Free PMC article.
Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice.
Jäntti H, Oksanen M, Kettunen P, Manta S, Mouledous L, Koivisto H, Ruuth J, Trontti K, Dhungana H, Keuters M, Weert I, Koskuvi M, Hovatta I, Linden AM, Rampon C, Malm T, Tanila H, Koistinaho J, Rolova T. Jäntti H, et al. Among authors: rolova t. Cells. 2022 Dec 18;11(24):4116. doi: 10.3390/cells11244116. Cells. 2022. PMID: 36552881 Free PMC article.
22 results