Huang Y - Search Results

1

Advances in inhibitor development targeting the PWWP domain.

Huang Y, Li Y, Min J. Huang Y, et al. Trends Pharmacol Sci. 2024 Mar;45(3):193-196. doi: 10.1016/j.tips.2024.01.007. Epub 2024 Feb 9. Trends Pharmacol Sci. 2024. PMID: 38341359

2

N/C-degron pathways and inhibitor development for PROTAC applications.

Wu Z, Huang Y, Liu K, Min J. Wu Z, et al. Among authors: huang y. Biochim Biophys Acta Gene Regul Mech. 2024 Mar;1867(1):194952. doi: 10.1016/j.bbagrm.2023.194952. Epub 2023 May 30. Biochim Biophys Acta Gene Regul Mech. 2024. PMID: 37263341 Review.

3

Inhibitors targeting the PWWP domain-containing proteins.

Huang Y, Li B, Wu Z, Liu K, Min J. Huang Y, et al. Eur J Med Chem. 2024 Dec 15;280:116965. doi: 10.1016/j.ejmech.2024.116965. Epub 2024 Oct 12. Eur J Med Chem. 2024. PMID: 39413441 Review.

4

Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria.

Xu Y, Zhang C, Jiang K, Yang X, Chen F, Cheng Z, Zhao J, Cheng J, Li X, Chen X, Zhou L, Duan H, Huang Y, Xiang Y, Li J. Xu Y, et al. Among authors: huang y. Acta Pharm Sin B. 2023 Apr;13(4):1671-1685. doi: 10.1016/j.apsb.2022.08.023. Epub 2022 Sep 5. Acta Pharm Sin B. 2023. PMID: 37139418 Free PMC article.

5

Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1.

Wang J, Huang Y, Shi K, Bao L, Xiao C, Sun T, Mao Z, Feng J, Hu Z, Guo Z, Li J, Jiang B, Liu W, Li J. Wang J, et al. Among authors: huang y. Oxid Med Cell Longev. 2022 Oct 11;2022:3151071. doi: 10.1155/2022/3151071. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 36267808 Free PMC article.

6

A Senomorphlytic Three-Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan.

Wang J, Liu W, Huang Y, Wang G, Guo X, Shi D, Sun T, Xiao C, Zhang C, Jiang B, Guo Y, Li J. Wang J, et al. Among authors: huang y. Adv Sci (Weinh). 2024 Sep;11(36):e2401862. doi: 10.1002/advs.202401862. Epub 2024 Jul 29. Adv Sci (Weinh). 2024. PMID: 39073681 Free PMC article.

7

Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.

Xu YX, Huang YY, Song RR, Ren YL, Chen X, Zhang C, Mao F, Li XK, Zhu J, Ni SS, Wan J, Li J. Xu YX, et al. Eur J Med Chem. 2020 Oct 1;203:112500. doi: 10.1016/j.ejmech.2020.112500. Epub 2020 Jul 15. Eur J Med Chem. 2020. PMID: 32711108

8

Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase.

Han X, Huang Y, Wei L, Chen H, Guo Y, Tang Z, Hu W, Xia Q, Wang Q, Yan J, Ren Y. Han X, et al. Among authors: huang y. Bioorg Med Chem. 2020 Sep 15;28(18):115624. doi: 10.1016/j.bmc.2020.115624. Epub 2020 Jul 10. Bioorg Med Chem. 2020. PMID: 32828433

9

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.

Wen W, Cao H, Huang Y, Tu J, Wan C, Wan J, Han X, Chen H, Liu J, Rao L, Su C, Peng C, Sheng C, Ren Y. Wen W, et al. Among authors: huang y. J Med Chem. 2022 Feb 10;65(3):2656-2674. doi: 10.1021/acs.jmedchem.1c02102. Epub 2022 Jan 31. J Med Chem. 2022. PMID: 35099959

10

N-Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction.

Wen W, Cao H, Xu Y, Ren Y, Rao L, Shao X, Chen H, Wu L, Liu J, Su C, Peng C, Huang Y, Wan J. Wen W, et al. Among authors: huang y. J Med Chem. 2022 Jul 14;65(13):9126-9143. doi: 10.1021/acs.jmedchem.2c00336. Epub 2022 Jul 4. J Med Chem. 2022. PMID: 35786925

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