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A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death.
Minnai F, Biscarini F, Esposito M, Dragani TA, Bujanda L, Rahmouni S, Alarcón-Riquelme ME, Bernardo D, Carnero-Montoro E, Buti M, Zeberg H, Asselta R, Romero-Gómez M; GEN-COVID Multicenter Study; Fernandez-Cadenas I, Fallerini C, Zguro K, Croci S, Baldassarri M, Bruttini M, Furini S, Renieri A, Colombo F. Minnai F, et al. Among authors: zeberg h. Sci Rep. 2024 Feb 6;14(1):3000. doi: 10.1038/s41598-024-53310-x. Sci Rep. 2024. PMID: 38321133 Free PMC article.
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Fallerini C, Picchiotti N, Baldassarri M, Zguro K, Daga S, Fava F, Benetti E, Amitrano S, Bruttini M, Palmieri M, Croci S, Lista M, Beligni G, Valentino F, Meloni I, Tanfoni M, Minnai F, Colombo F, Cabri E, Fratelli M, Gabbi C, Mantovani S, Frullanti E, Gori M, Crawley FP, Butler-Laporte G, Richards B, Zeberg H, Lipcsey M, Hultström M, Ludwig KU, Schulte EC, Pairo-Castineira E, Baillie JK, Schmidt A, Frithiof R; WES/WGS Working Group Within the HGI; GenOMICC Consortium; GEN-COVID Multicenter Study; Mari F, Renieri A, Furini S. Fallerini C, et al. Among authors: zeberg h. Hum Genet. 2022 Jan;141(1):147-173. doi: 10.1007/s00439-021-02397-7. Epub 2021 Dec 10. Hum Genet. 2022. PMID: 34889978 Free PMC article.
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity.
Yoshiji S, Butler-Laporte G, Lu T, Willett JDS, Su CY, Nakanishi T, Morrison DR, Chen Y, Liang K, Hultström M, Ilboudo Y, Afrasiabi Z, Lan S, Duggan N, DeLuca C, Vaezi M, Tselios C, Xue X, Bouab M, Shi F, Laurent L, Münter HM, Afilalo M, Afilalo J, Mooser V, Timpson NJ, Zeberg H, Zhou S, Forgetta V, Farjoun Y, Richards JB. Yoshiji S, et al. Among authors: zeberg h. Nat Metab. 2023 Feb;5(2):248-264. doi: 10.1038/s42255-023-00742-w. Epub 2023 Feb 20. Nat Metab. 2023. PMID: 36805566 Free PMC article.
Earliest modern human genomes constrain timing of Neanderthal admixture.
Sümer AP, Rougier H, Villalba-Mouco V, Huang Y, Iasi LNM, Essel E, Mesa AB, Furtwaengler A, Peyrégne S, de Filippo C, Rohrlach AB, Pierini F, Mafessoni F, Fewlass H, Zavala EI, Mylopotamitaki D, Bianco RA, Schmidt A, Zorn J, Nickel B, Patova A, Posth C, Smith GM, Ruebens K, Sinet-Mathiot V, Stoessel A, Dietl H, Orschiedt J, Kelso J, Zeberg H, Bos KI, Welker F, Weiss M, McPherron S, Schüler T, Hublin JJ, Velemínský P, Brůžek J, Peter BM, Meyer M, Meller H, Ringbauer H, Hajdinjak M, Prüfer K, Krause J. Sümer AP, et al. Among authors: zeberg h. Nature. 2024 Dec 12. doi: 10.1038/s41586-024-08420-x. Online ahead of print. Nature. 2024. PMID: 39667410
Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry.
Schuermans A, Verstraete A, Lammi V, Nakanishi T, Ardissino M, Van den Eynde J, Sun B, Georgakis MK, Guillen-Guio B, Wain LV, Brightling CE; PHOSP-COVID Collaborative Group; Van Weyenbergh J, Lewandowski AJ, Raman B, Zeberg H, Ollila HM, Burgess S, Natarajan P, Honigberg MC, Freson K, Vanassche T, Verhamme P. Schuermans A, et al. Among authors: zeberg h. medRxiv [Preprint]. 2024 Dec 12:2024.05.17.24307553. doi: 10.1101/2024.05.17.24307553. medRxiv. 2024. PMID: 38798608 Free PMC article. Preprint.
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Brunet-Ratnasingham E, Morin S, Randolph HE, Labrecque M, Bélair J, Lima-Barbosa R, Pagliuzza A, Marchitto L, Hultström M, Niessl J, Cloutier R, Sreng Flores AM, Brassard N, Benlarbi M, Prévost J, Ding S, Anand SP, Sannier G, Marks A, Wågsäter D, Bareke E, Zeberg H, Lipcsey M, Frithiof R, Larsson A, Zhou S, Nakanishi T, Morrison D, Vezina D, Bourassa C, Gendron-Lepage G, Medjahed H, Point F, Richard J, Larochelle C, Prat A, Cunningham JL, Arbour N, Durand M, Richards JB, Moon K, Chomont N, Finzi A, Tétreault M, Barreiro L, Wolf G, Kaufmann DE. Brunet-Ratnasingham E, et al. Among authors: zeberg h. Nat Commun. 2024 May 16;15(1):4177. doi: 10.1038/s41467-024-48556-y. Nat Commun. 2024. PMID: 38755196 Free PMC article.
The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling.
Xie M, Kaiser M, Gershtein Y, Schnyder D, Deviatiiarov R, Gazizova G, Shagimardanova E, Zikmund T, Kerckhofs G, Ivashkin E, Batkovskyte D, Newton PT, Andersson O, Fried K, Gusev O, Zeberg H, Kaiser J, Adameyko I, Chagin AS. Xie M, et al. Among authors: zeberg h. Nat Commun. 2024 Mar 26;15(1):2367. doi: 10.1038/s41467-024-46030-3. Nat Commun. 2024. PMID: 38531868 Free PMC article.
Homo sapiens reached the higher latitudes of Europe by 45,000 years ago.
Mylopotamitaki D, Weiss M, Fewlass H, Zavala EI, Rougier H, Sümer AP, Hajdinjak M, Smith GM, Ruebens K, Sinet-Mathiot V, Pederzani S, Essel E, Harking FS, Xia H, Hansen J, Kirchner A, Lauer T, Stahlschmidt M, Hein M, Talamo S, Wacker L, Meller H, Dietl H, Orschiedt J, Olsen JV, Zeberg H, Prüfer K, Krause J, Meyer M, Welker F, McPherron SP, Schüler T, Hublin JJ. Mylopotamitaki D, et al. Among authors: zeberg h. Nature. 2024 Feb;626(7998):341-346. doi: 10.1038/s41586-023-06923-7. Epub 2024 Jan 31. Nature. 2024. PMID: 38297117 Free PMC article.
62 results