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Microglia measured by TSPO PET are associated with Alzheimer's disease pathology and mediate key steps in a disease progression model.
Rossano SM, Johnson AS, Smith A, Ziaggi G, Roetman A, Guzman D, Okafor A, Klein J, Tomljanovic Z, Stern Y, Brickman AM, Lee S, Kreisl WC, Lao P. Rossano SM, et al. Among authors: ziaggi g. Alzheimers Dement. 2024 Apr;20(4):2397-2407. doi: 10.1002/alz.13699. Epub 2024 Feb 1. Alzheimers Dement. 2024. PMID: 38298155 Free PMC article.
Psychotic symptoms are associated with elevated tau PET signal in the amygdala independent of Alzheimer's disease clinical severity and amyloid burden.
Johnson AS, Ziaggi G, Smith AC, Houlihan H, Heuer LB, Guzmán DS, Okafor A, Huey ED, Talmasov D, Provenzano F, Kreisl WC, Lao PJ; Alzheimer’s Disease Neuroimaging Initiative. Johnson AS, et al. Among authors: ziaggi g. medRxiv [Preprint]. 2024 Jan 13:2024.01.12.24301221. doi: 10.1101/2024.01.12.24301221. medRxiv. 2024. PMID: 38260648 Free PMC article. Preprint.