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Page 1
Petabase-scale sequence alignment catalyses viral discovery.
Edgar RC, Taylor B, Lin V, Altman T, Barbera P, Meleshko D, Lohr D, Novakovsky G, Buchfink B, Al-Shayeb B, Banfield JF, de la Peña M, Korobeynikov A, Chikhi R, Babaian A. Edgar RC, et al. Nature. 2022 Feb;602(7895):142-147. doi: 10.1038/s41586-021-04332-2. Epub 2022 Jan 26. Nature. 2022. PMID: 35082445
Hybrids of RNA viruses and viroid-like elements replicate in fungi.
Forgia M, Navarro B, Daghino S, Cervera A, Gisel A, Perotto S, Aghayeva DN, Akinyuwa MF, Gobbi E, Zheludev IN, Edgar RC, Chikhi R, Turina M, Babaian A, Di Serio F, de la Peña M. Forgia M, et al. Among authors: edgar rc. Nat Commun. 2023 May 5;14(1):2591. doi: 10.1038/s41467-023-38301-2. Nat Commun. 2023. PMID: 37147358 Free PMC article.
Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance.
Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK, Economy JM, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, Melillo B, Mok S, Narwal SK, Ndiaye T, Ottilie S, Palomo Diaz S, Park H, Peña S, Rocamora F, Sakata-Kato T, Small-Saunders JL, Summers RL, Tumwebaze PK, Vanaerschot M, Xia G, Yeo T, You A, Gamo FJ, Goldberg DE, Lee MCS, McNamara CW, Ndiaye D, Rosenthal PJ, Schreiber SL, Serra G, De Siqueira-Neto JL, Skinner-Adams TS, Uhlemann AC, Kato N, Lukens AK, Wirth DF, Fidock DA, Winzeler EA. Luth MR, et al. Among authors: edgar rcs. Science. 2024 Nov 29;386(6725):eadk9893. doi: 10.1126/science.adk9893. Epub 2024 Nov 29. Science. 2024. PMID: 39607932
Viroid-like colonists of human microbiomes.
Zheludev IN, Edgar RC, Lopez-Galiano MJ, de la Peña M, Babaian A, Bhatt AS, Fire AZ. Zheludev IN, et al. Among authors: edgar rc. Cell. 2024 Nov 14;187(23):6521-6536.e18. doi: 10.1016/j.cell.2024.09.033. Epub 2024 Oct 30. Cell. 2024. PMID: 39481381
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.
Edgar RCS, Malcolm TR, Siddiqui G, Giannangelo C, Counihan NA, Challis M, Duffy S, Chowdhury M, Marfurt J, Dans M, Wirjanata G, Noviyanti R, Daware K, Suraweera CD, Price RN, Wittlin S, Avery VM, Drinkwater N, Charman SA, Creek DJ, de Koning-Ward TF, Scammells PJ, McGowan S. Edgar RCS, et al. mBio. 2024 Jun 12;15(6):e0096624. doi: 10.1128/mbio.00966-24. Epub 2024 May 8. mBio. 2024. PMID: 38717141 Free PMC article.
186 results