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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. Xia W, et al. Among authors: veeragandham p. Nat Metab. 2024 Feb;6(2):273-289. doi: 10.1038/s42255-024-00978-0. Epub 2024 Jan 29. Nat Metab. 2024. PMID: 38286821 Free PMC article.
Obesity-dependent increase in RalA activity disrupts mitochondrial dynamics in white adipocytes.
Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne T, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu R, Downes M, Evans R, Ryden M, Wabitsch M, Reilly S, Huang J, Saltiel A. Xia W, et al. Among authors: veeragandham p. Res Sq [Preprint]. 2023 Jun 2:rs.3.rs-2923510. doi: 10.21203/rs.3.rs-2923510/v1. Res Sq. 2023. Update in: Nat Metab. 2024 Feb;6(2):273-289. doi: 10.1038/s42255-024-00978-0 PMID: 37398165 Free PMC article. Updated. Preprint.