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Edaravone and obeticholic acid protect against cisplatin-induced heart toxicity by suppressing oxidative stress and inflammation and modulating Nrf2, TLR4/p38MAPK, and JAK1/STAT3/NF-κB signals.
El-Shoura EAM, Hassanein EHM, Taha HH, Shalkami AS, Hassanein MMH, Ali FEM, Bakr AG. El-Shoura EAM, et al. Among authors: hassanein mmh. Naunyn Schmiedebergs Arch Pharmacol. 2024 Aug;397(8):5649-5662. doi: 10.1007/s00210-024-02956-5. Epub 2024 Jan 29. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 38285279 Free PMC article.