Singh S - Search Results

1

Efficient and sustained FOXP3 locus editing in hematopoietic stem cells as a therapeutic approach for IPEX syndrome.

Singh S, Pugliano CM, Honaker Y, Laird A, DeGottardi MQ, Lopez E, Lachkar S, Stoffers C, Sommer K, Khan IF, Rawlings DJ. Singh S, et al. Mol Ther Methods Clin Dev. 2023 Dec 26;32(1):101183. doi: 10.1016/j.omtm.2023.101183. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2023. PMID: 38282895 Free PMC article.

2

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector.

Singh S, Khan I, Khim S, Seymour B, Sommer K, Wielgosz M, Norgaard Z, Kiem HP, Adair J, Liggitt D, Nienhuis A, Rawlings DJ. Singh S, et al. Mol Ther Methods Clin Dev. 2016 Dec 18;4:1-16. doi: 10.1016/j.omtm.2016.11.001. eCollection 2017 Mar 17. Mol Ther Methods Clin Dev. 2016. PMID: 28344987 Free PMC article.

3

Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector.

Seymour BJ, Singh S, Certo HM, Sommer K, Sather BD, Khim S, Clough C, Hale M, Pangallo J, Ryu BY, Khan IF, Adair JE, Rawlings DJ. Seymour BJ, et al. Among authors: singh s. Mol Ther Methods Clin Dev. 2021 Jan 20;20:635-651. doi: 10.1016/j.omtm.2021.01.007. eCollection 2021 Mar 12. Mol Ther Methods Clin Dev. 2021. PMID: 33718514 Free PMC article.

4

Efficient modification of CCR5 in primary human hematopoietic cells using a megaTAL nuclease and AAV donor template.

Sather BD, Romano Ibarra GS, Sommer K, Curinga G, Hale M, Khan IF, Singh S, Song Y, Gwiazda K, Sahni J, Jarjour J, Astrakhan A, Wagner TA, Scharenberg AM, Rawlings DJ. Sather BD, et al. Among authors: singh s. Sci Transl Med. 2015 Sep 30;7(307):307ra156. doi: 10.1126/scitranslmed.aac5530. Sci Transl Med. 2015. PMID: 26424571 Free PMC article.

5

Engineering Protein-Secreting Plasma Cells by Homology-Directed Repair in Primary Human B Cells.

Hung KL, Meitlis I, Hale M, Chen CY, Singh S, Jackson SW, Miao CH, Khan IF, Rawlings DJ, James RG. Hung KL, et al. Among authors: singh s. Mol Ther. 2018 Feb 7;26(2):456-467. doi: 10.1016/j.ymthe.2017.11.012. Epub 2017 Nov 22. Mol Ther. 2018. PMID: 29273498 Free PMC article.

6

Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.

Wang CX, Sather BD, Wang X, Adair J, Khan I, Singh S, Lang S, Adams A, Curinga G, Kiem HP, Miao CH, Rawlings DJ, Torbett BE. Wang CX, et al. Among authors: singh s. Blood. 2014 Aug 7;124(6):913-23. doi: 10.1182/blood-2013-12-546218. Epub 2014 Jun 9. Blood. 2014. PMID: 24914132 Free PMC article.

7

In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods.

Pattabhi S, Lotti SN, Berger MP, Singh S, Lux CT, Jacoby K, Lee C, Negre O, Scharenberg AM, Rawlings DJ. Pattabhi S, et al. Among authors: singh s. Mol Ther Nucleic Acids. 2019 Sep 6;17:277-288. doi: 10.1016/j.omtn.2019.05.025. Epub 2019 Jun 7. Mol Ther Nucleic Acids. 2019. PMID: 31279229 Free PMC article.

8

Ex vivo engineered human plasma cells exhibit robust protein secretion and long-term engraftment in vivo.

Cheng RY, Hung KL, Zhang T, Stoffers CM, Ott AR, Suchland ER, Camp ND, Khan IF, Singh S, Yang YJ, Rawlings DJ, James RG. Cheng RY, et al. Among authors: singh s. Nat Commun. 2022 Oct 16;13(1):6110. doi: 10.1038/s41467-022-33787-8. Nat Commun. 2022. PMID: 36245034 Free PMC article.

9

Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.

Astrakhan A, Sather BD, Ryu BY, Khim S, Singh S, Humblet-Baron S, Ochs HD, Miao CH, Rawlings DJ. Astrakhan A, et al. Among authors: singh s. Blood. 2012 May 10;119(19):4395-407. doi: 10.1182/blood-2011-03-340711. Epub 2012 Mar 19. Blood. 2012. PMID: 22431569 Free PMC article.

10

Intraosseous delivery of platelet-targeted factor VIII lentiviral vector in humanized NBSGW mice.

Joo JH, Wang X, Singh S, Chen CY, Li C, Adair JE, Kiem HP, Rawlings DJ, Miao CH. Joo JH, et al. Among authors: singh s. Blood Adv. 2022 Oct 11;6(19):5556-5569. doi: 10.1182/bloodadvances.2022008079. Blood Adv. 2022. PMID: 35849710 Free PMC article.

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