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Page 1
Fecal-adherent mucus is a non-invasive source of primary human MUC2 for structural and functional characterization in health and disease.
Fancy N, Nitin, Kniffen D, Melvin M, Kazemian N, Sadeghi J, Letef CA, D'Aloisio L, Copp AG, Inaba R, Hans G, Jafaripour S, Haskey N, Raman M, Daneshgar P, Chadee K, Ghosh S, Gibson DL, Pakpour S, Zandberg W, Bergstrom KSB. Fancy N, et al. Among authors: zandberg w. J Biol Chem. 2024 Mar;300(3):105675. doi: 10.1016/j.jbc.2024.105675. Epub 2024 Jan 24. J Biol Chem. 2024. PMID: 38272223 Free PMC article.
Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2.
Lira-Navarrete E, Iglesias-Fernández J, Zandberg WF, Compañón I, Kong Y, Corzana F, Pinto BM, Clausen H, Peregrina JM, Vocadlo DJ, Rovira C, Hurtado-Guerrero R. Lira-Navarrete E, et al. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8206-10. doi: 10.1002/anie.201402781. Epub 2014 Jun 20. Angew Chem Int Ed Engl. 2014. PMID: 24954443
HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Lazarus MB, Jiang J, Kapuria V, Bhuiyan T, Janetzko J, Zandberg WF, Vocadlo DJ, Herr W, Walker S. Lazarus MB, et al. Among authors: zandberg wf. Science. 2013 Dec 6;342(6163):1235-9. doi: 10.1126/science.1243990. Science. 2013. PMID: 24311690 Free PMC article.
Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota.
Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Bergstrom K, et al. Among authors: zandberg w. Science. 2020 Oct 23;370(6515):467-472. doi: 10.1126/science.aay7367. Science. 2020. PMID: 33093110 Free PMC article.
A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies.
Gilormini PA, Thota VN, Fers-Lidou A, Ashmus RA, Nodwell M, Brockerman J, Kuo CW, Wang Y, Gray TE, Nitin, McDonagh AW, Guu SY, Ertunc N, Yeo D, Zandberg WF, Khoo KH, Britton R, Vocadlo DJ. Gilormini PA, et al. Among authors: zandberg wf. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2314026121. doi: 10.1073/pnas.2314026121. Epub 2024 Jun 25. Proc Natl Acad Sci U S A. 2024. PMID: 38917011 Free PMC article.
53 results