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Chromatin Remodeling in Patient-Derived Colorectal Cancer Models.
Xiang K, Wang E, Mantyh J, Rupprecht G, Negrete M, Sanati G, Hsu C, Randon P, Dohlman A, Kretzschmar K, Bose S, Giroux N, Ding S, Wang L, Balcazar JP, Huang Q, Sundaramoorthy P, Xi R, McCall SJ, Wang Z, Jiang C, Kang Y, Kopetz S, Crawford GE, Lipkin SM, Wang XF, Clevers H, Hsu D, Shen X. Xiang K, et al. Among authors: clevers h. Adv Sci (Weinh). 2024 Apr;11(16):e2303379. doi: 10.1002/advs.202303379. Epub 2024 Feb 21. Adv Sci (Weinh). 2024. PMID: 38380561 Free PMC article.
Reuniting philosophy and science to advance cancer research.
Pradeu T, Daignan-Fornier B, Ewald A, Germain PL, Okasha S, Plutynski A, Benzekry S, Bertolaso M, Bissell M, Brown JS, Chin-Yee B, Chin-Yee I, Clevers H, Cognet L, Darrason M, Farge E, Feunteun J, Galon J, Giroux E, Green S, Gross F, Jaulin F, Knight R, Laconi E, Larmonier N, Maley C, Mantovani A, Moreau V, Nassoy P, Rondeau E, Santamaria D, Sawai CM, Seluanov A, Sepich-Poore GD, Sisirak V, Solary E, Yvonnet S, Laplane L. Pradeu T, et al. Among authors: clevers h. Biol Rev Camb Philos Soc. 2023 Oct;98(5):1668-1686. doi: 10.1111/brv.12971. Epub 2023 May 8. Biol Rev Camb Philos Soc. 2023. PMID: 37157910 Free PMC article.
Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer.
Plattner C, Lamberti G, Blattmann P, Kirchmair A, Rieder D, Loncova Z, Sturm G, Scheidl S, Ijsselsteijn M, Fotakis G, Noureen A, Lisandrelli R, Böck N, Nemati N, Krogsdam A, Daum S, Finotello F, Somarakis A, Schäfer A, Wilflingseder D, Gonzalez Acera M, Öfner D, Huber LA, Clevers H, Becker C, Farin HF, Greten FR, Aebersold R, de Miranda NFCC, Trajanoski Z. Plattner C, et al. Among authors: clevers h. iScience. 2023 Nov 4;26(12):108399. doi: 10.1016/j.isci.2023.108399. eCollection 2023 Dec 15. iScience. 2023. PMID: 38047086 Free PMC article.
Integrin-activating Yersinia protein Invasin sustains long-term expansion of primary epithelial cells as 2D organoid sheets.
Wijnakker JJAPM, van Son GJF, Krueger D, van de Wetering WJ, Lopez-Iglesias C, Schreurs R, van Rijt F, Lim S, Lin L, Peters PJ, Isberg RR, Janda CY, de Lau W, Clevers H. Wijnakker JJAPM, et al. Among authors: clevers h. Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2420595121. doi: 10.1073/pnas.2420595121. Epub 2024 Dec 30. Proc Natl Acad Sci U S A. 2025. PMID: 39793062 Free PMC article.
Human respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction.
Li C, Yu Y, Wan Z, Chiu MC, Huang J, Zhang S, Zhu X, Lan Q, Deng Y, Zhou Y, Xue W, Yue M, Cai JP, Yip CC, Wong KK, Liu X, Yu Y, Huang L, Chu H, Chan JF, Clevers H, Yuen KY, Zhou J. Li C, et al. Among authors: clevers h. Nat Commun. 2024 Dec 30;15(1):10772. doi: 10.1038/s41467-024-55076-2. Nat Commun. 2024. PMID: 39738014 Free PMC article.
RANK drives structured intestinal epithelial expansion during pregnancy.
Onji M, Sigl V, Lendl T, Novatchkova M, Ullate-Agote A, Andersson-Rolf A, Kozieradzki I, Koglgruber R, Pai TP, Lichtscheidl D, Nayak K, Zilbauer M, Carranza García NA, Sievers LK, Falk-Paulsen M, Cronin SJF, Hagelkruys A, Sawa S, Osborne LC, Rosenstiel P, Pasparakis M, Ruland J, Takayanagi H, Clevers H, Koo BK, Penninger JM. Onji M, et al. Among authors: clevers h. Nature. 2025 Jan;637(8044):156-166. doi: 10.1038/s41586-024-08284-1. Epub 2024 Dec 4. Nature. 2025. PMID: 39633049 Free PMC article.
836 results