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Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: o connor jj. bioRxiv [Preprint]. 2024 Jul 12:2024.01.03.574082. doi: 10.1101/2024.01.03.574082. bioRxiv. 2024. Update in: J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24 PMID: 38260573 Free PMC article. Updated. Preprint.
An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication.
Voth LS, O'Connor JJ, Kerr CM, Doerger E, Schwarting N, Sperstad P, Johnson DK, Fehr AR. Voth LS, et al. bioRxiv [Preprint]. 2021 Mar 31:2021.03.30.437796. doi: 10.1101/2021.03.30.437796. bioRxiv. 2021. Update in: J Virol. 2021 Jul 12;95(15):e0076621. doi: 10.1128/JVI.00766-21 PMID: 33821264 Free PMC article. Updated. Preprint.
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice.
Alhammad YM, Parthasarathy S, Ghimire R, O'Connor JJ, Kerr CM, Pfannenstiel JJ, Chanda D, Miller CA, Unckless RL, Zuniga S, Enjuanes L, More S, Channappanavar R, Fehr AR. Alhammad YM, et al. bioRxiv [Preprint]. 2023 Apr 6:2023.04.06.535927. doi: 10.1101/2023.04.06.535927. bioRxiv. 2023. Update in: Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2302083120. doi: 10.1073/pnas.2302083120 PMID: 37066301 Free PMC article. Updated. Preprint.
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner.
Kerr CM, Parthasarathy S, Schwarting N, O'Connor JJ, Giri E, More S, Orozco RC, Fehr AR. Kerr CM, et al. Among authors: o connor jj. bioRxiv [Preprint]. 2023 Jun 17:2023.06.16.545351. doi: 10.1101/2023.06.16.545351. bioRxiv. 2023. Update in: J Virol. 2023 Sep 28;97(9):e0088523. doi: 10.1128/jvi.00885-23 PMID: 37398292 Free PMC article. Updated. Preprint.
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: o connor jj. J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24. Epub 2024 Oct 10. J Virol. 2024. PMID: 39387584 Free article.
Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication.
Pfannenstiel JJ, Duong MTH, Cluff D, Sherrill LM, Colquhoun I, Cadoux G, Thorne D, Pääkkönen J, Schemmel NF, O'Connor J, Saenjamsai P, Feng M, Hageman MJ, Johnson DK, Roy A, Lehtiö L, Ferraris DV, Fehr AR. Pfannenstiel JJ, et al. bioRxiv [Preprint]. 2024 Oct 29:2024.10.28.620664. doi: 10.1101/2024.10.28.620664. bioRxiv. 2024. PMID: 39554145 Free PMC article. Preprint.
Emc1 is essential for vision and zebrafish photoreceptor outer segment morphogenesis.
McCann T, Sundaramurthi H, Walsh C, Virdi S, Alvarez Y, Sapetto-Rebow B, Collery RF, Carter SP, Moran A, Mulholland R, O'Connor JJ, Taylor MR, Rauch N, Starostik MR, English MA, Swaroop A, Geisler R, Reynolds AL, Kennedy BN. McCann T, et al. Among authors: o connor jj. FASEB J. 2024 Oct 15;38(19):e70086. doi: 10.1096/fj.202401977R. FASEB J. 2024. PMID: 39360639
300 results