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Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection.
Kerr CM, Pfannenstiel JJ, Alhammad YM, O'Connor JJ, Ghimire R, Shrestha R, Khattabi R, Saenjamsai P, Parthasarathy S, McDonald PR, Gao P, Johnson DK, More S, Roy A, Channappanavar R, Fehr AR. Kerr CM, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2024 Jul 12:2024.01.03.574082. doi: 10.1101/2024.01.03.574082. bioRxiv. 2024. Update in: J Virol. 2024 Nov 19;98(11):e0131324. doi: 10.1128/jvi.01313-24 PMID: 38260573 Free PMC article. Updated. Preprint.
Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity.
Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Heer CD, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2020 Oct 6:2020.04.17.047480. doi: 10.1101/2020.04.17.047480. bioRxiv. 2020. Update in: J Biol Chem. 2020 Dec 25;295(52):17986-17996. doi: 10.1074/jbc.RA120.015138 PMID: 32511303 Free PMC article. Updated. Preprint.
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase.
Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2020 Oct 28:2020.05.11.089375. doi: 10.1101/2020.05.11.089375. bioRxiv. 2020. Update in: J Virol. 2021 Jan 13;95(3):e01969-20. doi: 10.1128/JVI.01969-20 PMID: 32511412 Free PMC article. Updated. Preprint.
60 results