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Simple models to understand complex disease: 10 years of progress from Caenorhabditis elegans models of amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Front Neurosci. 2024 Jan 4;17:1300705. doi: 10.3389/fnins.2023.1300705. eCollection 2023.
Front Neurosci. 2024.
PMID: 38239833
Free PMC article.
Review.
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.
Latimer CS, Stair JG, Hincks JC, Currey HN, Bird TD, Keene CD, Kraemer BC, Liachko NF.
Latimer CS, et al. Among authors: stair jg.
Dis Model Mech. 2022 Apr 1;15(4):dmm049323. doi: 10.1242/dmm.049323. Epub 2022 Apr 27.
Dis Model Mech. 2022.
PMID: 35178571
Free PMC article.
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Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets.
Jadhav VS, Stair JG, Eck RJ, Smukowski SN, Currey HN, Toscano LG, Hincks JC, Latimer CS, Valdmanis PN, Kraemer BC, Liachko NF.
Jadhav VS, et al. Among authors: stair jg.
Neurobiol Dis. 2024 Apr;193:106441. doi: 10.1016/j.nbd.2024.106441. Epub 2024 Feb 18.
Neurobiol Dis. 2024.
PMID: 38378122
Free PMC article.
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Decreased Hsp90 activity protects against TDP-43 neurotoxicity in a C. elegans model of amyotrophic lateral sclerosis.
Garcia-Toscano L, Currey HN, Hincks JC, Stair JG, Lehrbach NJ, Liachko NF.
Garcia-Toscano L, et al. Among authors: stair jg.
PLoS Genet. 2024 Dec 26;20(12):e1011518. doi: 10.1371/journal.pgen.1011518. eCollection 2024 Dec.
PLoS Genet. 2024.
PMID: 39724103
Free PMC article.
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