Plückthun A - Search Results

1

Identification of a Novel Subtype-Selective α_1B-Adrenoceptor Antagonist.

Abdul-Ridha A, de Zhang LA, Betrie AH, Deluigi M, Vaid TM, Whitehead A, Zhang Y, Davis B, Harris R, Simmonite H, Hubbard RE, Gooley PR, Plückthun A, Bathgate RAD, Chalmers DK, Scott DJ. Abdul-Ridha A, et al. Among authors: pluckthun a. ACS Chem Neurosci. 2024 Feb 7;15(3):671-684. doi: 10.1021/acschemneuro.3c00767. Epub 2024 Jan 18. ACS Chem Neurosci. 2024. PMID: 38238043 Free PMC article.

2

Direct molecular evolution of detergent-stable G protein-coupled receptors using polymer encapsulated cells.

Scott DJ, Plückthun A. Scott DJ, et al. Among authors: pluckthun a. J Mol Biol. 2013 Feb 8;425(3):662-77. doi: 10.1016/j.jmb.2012.11.015. Epub 2012 Nov 16. J Mol Biol. 2013. PMID: 23164568

3

Stabilizing membrane proteins through protein engineering.

Scott DJ, Kummer L, Tremmel D, Plückthun A. Scott DJ, et al. Among authors: pluckthun a. Curr Opin Chem Biol. 2013 Jun;17(3):427-35. doi: 10.1016/j.cbpa.2013.04.002. Epub 2013 Apr 29. Curr Opin Chem Biol. 2013. PMID: 23639904 Review.

4

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in Escherichia coli.

Egloff P, Hillenbrand M, Klenk C, Batyuk A, Heine P, Balada S, Schlinkmann KM, Scott DJ, Schütz M, Plückthun A. Egloff P, et al. Among authors: pluckthun a. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E655-62. doi: 10.1073/pnas.1317903111. Epub 2014 Jan 22. Proc Natl Acad Sci U S A. 2014. PMID: 24453215 Free PMC article.

5

Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies.

Scott DJ, Kummer L, Egloff P, Bathgate RA, Plückthun A. Scott DJ, et al. Among authors: pluckthun a. Biochim Biophys Acta. 2014 Nov;1838(11):2817-24. doi: 10.1016/j.bbamem.2014.07.015. Epub 2014 Jul 23. Biochim Biophys Acta. 2014. PMID: 25064156 Free article.

6

A cleavable ligand column for the rapid isolation of large quantities of homogeneous and functional neurotensin receptor 1 variants from E. coli.

Egloff P, Deluigi M, Heine P, Balada S, Plückthun A. Egloff P, et al. Among authors: pluckthun a. Protein Expr Purif. 2015 Apr;108:106-114. doi: 10.1016/j.pep.2014.10.006. Epub 2014 Oct 20. Protein Expr Purif. 2015. PMID: 25461958

7

Determinants of Ligand Subtype-Selectivity at α_1A-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR.

Yong KJ, Vaid TM, Shilling PJ, Wu FJ, Williams LM, Deluigi M, Plückthun A, Bathgate RAD, Gooley PR, Scott DJ. Yong KJ, et al. Among authors: pluckthun a. ACS Chem Biol. 2018 Apr 20;13(4):1090-1102. doi: 10.1021/acschembio.8b00191. Epub 2018 Mar 22. ACS Chem Biol. 2018. PMID: 29537256

8

Optimizing the α_1B-adrenergic receptor for solution NMR studies.

Schuster M, Deluigi M, Pantić M, Vacca S, Baumann C, Scott DJ, Plückthun A, Zerbe O. Schuster M, et al. Among authors: pluckthun a. Biochim Biophys Acta Biomembr. 2020 Oct 1;1862(10):183354. doi: 10.1016/j.bbamem.2020.183354. Epub 2020 May 13. Biochim Biophys Acta Biomembr. 2020. PMID: 32413443 Free article.

9

Crystal structure of the α_1B-adrenergic receptor reveals molecular determinants of selective ligand recognition.

Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge RR, de Zhang LA, Klipp A, Vacca S, Vaid TM, Mittl PRE, Egloff P, Eberle SA, Zerbe O, Chalmers DK, Scott DJ, Plückthun A. Deluigi M, et al. Among authors: pluckthun a. Nat Commun. 2022 Jan 19;13(1):382. doi: 10.1038/s41467-021-27911-3. Nat Commun. 2022. PMID: 35046410 Free PMC article.

10

Side-chain dynamics of the α_1B -adrenergic receptor determined by NMR via methyl relaxation.

Baumann C, Chiang WC, Valsecchi R, Jurt S, Deluigi M, Schuster M, Rosengren KJ, Plückthun A, Zerbe O. Baumann C, et al. Among authors: pluckthun a. Protein Sci. 2023 Nov;32(11):e4801. doi: 10.1002/pro.4801. Protein Sci. 2023. PMID: 37805830 Free PMC article.

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