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D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histocompatibility class II expression in non-malignant dendritic cells and acute myeloid leukemia cells.
Hammon K, Renner K, Althammer M, Voll F, Babl N, Decking SM, Siska PJ, Matos C, Conejo ZEC, Mendes K, Einwag F, Siegmund H, Iberl S, Berger RS, Dettmer K, Schoenmehl R, Brochhausen C, Herr W, Oefner PJ, Rehli M, Thomas S, Kreutz M. Hammon K, et al. Among authors: siska pj. Haematologica. 2024 Aug 1;109(8):2500-2514. doi: 10.3324/haematol.2023.283597. Haematologica. 2024. PMID: 38235501 Free PMC article.
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS Jr, Irish JM, Newcomb DC, Rathmell JC. Healey DCC, et al. Among authors: siska pj. J Immunol. 2021 Mar 15;206(6):1127-1139. doi: 10.4049/jimmunol.2001029. Epub 2021 Feb 8. J Immunol. 2021. PMID: 33558372 Free PMC article.
Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Siska PJ, et al. JCI Insight. 2017 Jun 15;2(12):e93411. doi: 10.1172/jci.insight.93411. eCollection 2017 Jun 15. JCI Insight. 2017. PMID: 28614802 Free PMC article.
Metabolic Signaling Drives IFN-γ.
Siska PJ, Rathmell JC. Siska PJ, et al. Cell Metab. 2016 Nov 8;24(5):651-652. doi: 10.1016/j.cmet.2016.10.018. Cell Metab. 2016. PMID: 27829134 Free PMC article.
Nutrients and the microenvironment to feed a T cell army.
Johnson MO, Siska PJ, Contreras DC, Rathmell JC. Johnson MO, et al. Among authors: siska pj. Semin Immunol. 2016 Oct;28(5):505-513. doi: 10.1016/j.smim.2016.09.003. Epub 2016 Oct 3. Semin Immunol. 2016. PMID: 27712958 Free PMC article. Review.
Immunometabolism in cancer at a glance.
Singer K, Cheng WC, Kreutz M, Ho PC, Siska PJ. Singer K, et al. Among authors: siska pj. Dis Model Mech. 2018 Aug 2;11(8):dmm034272. doi: 10.1242/dmm.034272. Dis Model Mech. 2018. PMID: 30076128 Free PMC article. Review.
Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells.
Renner K, Seilbeck A, Kauer N, Ugele I, Siska PJ, Brummer C, Bruss C, Decking SM, Fante M, Schmidt A, Hammon K, Singer K, Klobuch S, Thomas S, Gottfried E, Peter K, Kreutz M. Renner K, et al. Among authors: siska pj. Front Pharmacol. 2018 Nov 2;9:1258. doi: 10.3389/fphar.2018.01258. eCollection 2018. Front Pharmacol. 2018. PMID: 30450049 Free PMC article.
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