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Page 1
Activity-assembled nBAF complex mediates rapid immediate early gene transcription by regulating RNA Polymerase II productive elongation.
Cornejo KG, Venegas A, Sono MH, Door M, Gutierrez-Ruiz B, Karabedian LB, Nandi SG, Dykhuizen EC, Saha RN. Cornejo KG, et al. Among authors: dykhuizen ec. bioRxiv [Preprint]. 2023 Dec 30:2023.12.30.573688. doi: 10.1101/2023.12.30.573688. bioRxiv. 2023. Update in: Cell Rep. 2024 Nov 26;43(11):114877. doi: 10.1016/j.celrep.2024.114877 PMID: 38234780 Free PMC article. Updated. Preprint.
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development.
Tinsley SL, Shelley RA, Mall GK, Chianis ERD, Dhiman A, Baral G, Kothandaraman H, Thoma MC, Daniel CJ, Lanman NA, di Magliano MP, Narla G, Solorio L, Dykhuizen EC, Sears RC, Allen-Petersen BL. Tinsley SL, et al. Among authors: dykhuizen ec. bioRxiv [Preprint]. 2024 May 23:2023.07.01.547283. doi: 10.1101/2023.07.01.547283. bioRxiv. 2024. Update in: Oncogene. 2024 Dec;43(50):3673-3687. doi: 10.1038/s41388-024-03196-w PMID: 38826439 Free PMC article. Updated. Preprint.
KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development.
Tinsley SL, Chianis ERD, Shelley RA, Mall GK, Dhiman A, Baral G, Kothandaraman H, Thoma MC, English IA, Daniel CJ, Acosta LCS, Solorio L, Atallah Lanman N, Pasca di Magliano M, Narla G, Dykhuizen EC, Sears RC, Allen-Petersen BL. Tinsley SL, et al. Among authors: dykhuizen ec. Oncogene. 2024 Dec;43(50):3673-3687. doi: 10.1038/s41388-024-03196-w. Epub 2024 Oct 23. Oncogene. 2024. PMID: 39443726
ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity.
Maxwell MB, Hom-Tedla MS, Yi J, Li S, Rivera SA, Yu J, Burns MJ, McRae HM, Stevenson BT, Coakley KE, Ho J, Gastelum KB, Bell JC, Jones AC, Eskander RN, Dykhuizen EC, Shadel GS, Kaech SM, Hargreaves DC. Maxwell MB, et al. Among authors: dykhuizen ec. Cell. 2024 Jun 20;187(13):3390-3408.e19. doi: 10.1016/j.cell.2024.04.025. Epub 2024 May 15. Cell. 2024. PMID: 38754421
PBRM1 bromodomains associate with RNA to facilitate chromatin association.
De Silva SM, Dhiman A, Sood S, Mercedes KF, Simmons WJ, Henen MA, Vögeli B, Dykhuizen EC, Musselman CA. De Silva SM, et al. Among authors: dykhuizen ec. Nucleic Acids Res. 2023 May 8;51(8):3631-3649. doi: 10.1093/nar/gkad072. Nucleic Acids Res. 2023. PMID: 36808431 Free PMC article.
Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.
Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Shishodia S, et al. Among authors: dykhuizen ec. J Med Chem. 2022 Oct 27;65(20):13714-13735. doi: 10.1021/acs.jmedchem.2c00864. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36227159 Free PMC article.
41 results