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Affinity-optimizing enhancer variants disrupt development.
Nature. 2024 Feb;626(7997):151-159. doi: 10.1038/s41586-023-06922-8. Epub 2024 Jan 17.
Nature. 2024.
PMID: 38233525
Free PMC article.
Predictive analyses of regulatory sequences with EUGENe.
Klie A, Laub D, Talwar JV, Stites H, Jores T, Solvason JJ, Farley EK, Carter H.
Klie A, et al. Among authors: solvason jj.
Nat Comput Sci. 2023 Nov;3(11):946-956. doi: 10.1038/s43588-023-00544-w. Epub 2023 Nov 16.
Nat Comput Sci. 2023.
PMID: 38177592
Free PMC article.
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Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development.
Jindal GA, Bantle AT, Solvason JJ, Grudzien JL, D'Antonio-Chronowska A, Lim F, Le SH, Song BP, Ragsac MF, Klie A, Larsen RO, Frazer KA, Farley EK.
Jindal GA, et al. Among authors: solvason jj.
Dev Cell. 2023 Nov 6;58(21):2206-2216.e5. doi: 10.1016/j.devcel.2023.09.005. Epub 2023 Oct 16.
Dev Cell. 2023.
PMID: 37848026
Free PMC article.
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