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Affinity-optimizing enhancer variants disrupt development.
Lim F, Solvason JJ, Ryan GE, Le SH, Jindal GA, Steffen P, Jandu SK, Farley EK. Lim F, et al. Among authors: farley ek. Nature. 2024 Feb;626(7997):151-159. doi: 10.1038/s41586-023-06922-8. Epub 2024 Jan 17. Nature. 2024. PMID: 38233525 Free PMC article.
Diverse logics and grammar encode notochord enhancers.
Song BP, Ragsac MF, Tellez K, Jindal GA, Grudzien JL, Le SH, Farley EK. Song BP, et al. Among authors: farley ek. Cell Rep. 2023 Feb 28;42(2):112052. doi: 10.1016/j.celrep.2023.112052. Epub 2023 Jan 31. Cell Rep. 2023. PMID: 36729834 Free PMC article.
Conserved enhancer logic controls the notochord expression of vertebrate Brachyury.
Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A. Kemmler CL, et al. bioRxiv [Preprint]. 2023 Apr 20:2023.04.20.536761. doi: 10.1101/2023.04.20.536761. bioRxiv. 2023. Update in: Nat Commun. 2023 Oct 18;14(1):6594. doi: 10.1038/s41467-023-42151-3 PMID: 37131681 Free PMC article. Updated. Preprint.
Conserved enhancers control notochord expression of vertebrate Brachyury.
Kemmler CL, Smolikova J, Moran HR, Mannion BJ, Knapp D, Lim F, Czarkwiani A, Hermosilla Aguayo V, Rapp V, Fitch OE, Bötschi S, Selleri L, Farley E, Braasch I, Yun M, Visel A, Osterwalder M, Mosimann C, Kozmik Z, Burger A. Kemmler CL, et al. Nat Commun. 2023 Oct 18;14(1):6594. doi: 10.1038/s41467-023-42151-3. Nat Commun. 2023. PMID: 37852970 Free PMC article.
Predictive analyses of regulatory sequences with EUGENe.
Klie A, Laub D, Talwar JV, Stites H, Jores T, Solvason JJ, Farley EK, Carter H. Klie A, et al. Among authors: farley ek. Nat Comput Sci. 2023 Nov;3(11):946-956. doi: 10.1038/s43588-023-00544-w. Epub 2023 Nov 16. Nat Comput Sci. 2023. PMID: 38177592 Free PMC article.
25 results