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Page 1
Allosteric activation of T cell antigen receptor signaling by quaternary structure relaxation.
Lanz AL, Masi G, Porciello N, Cohnen A, Cipria D, Prakaash D, Bálint Š, Raggiaschi R, Galgano D, Cole DK, Lepore M, Dushek O, Dustin ML, Sansom MSP, Kalli AC, Acuto O. Lanz AL, et al. Among authors: dushek o. Cell Rep. 2021 Aug 10;36(6):109531. doi: 10.1016/j.celrep.2021.109531. Cell Rep. 2021. PMID: 34380025 Free PMC article. No abstract available.
Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.
Jönsson P, Southcombe JH, Santos AM, Huo J, Fernandes RA, McColl J, Lever M, Evans EJ, Hudson A, Chang VT, Hanke T, Godkin A, Dunne PD, Horrocks MH, Palayret M, Screaton GR, Petersen J, Rossjohn J, Fugger L, Dushek O, Xu XN, Davis SJ, Klenerman D. Jönsson P, et al. Among authors: dushek o. Proc Natl Acad Sci U S A. 2016 May 17;113(20):5682-7. doi: 10.1073/pnas.1513918113. Epub 2016 Apr 25. Proc Natl Acad Sci U S A. 2016. PMID: 27114505 Free PMC article.
A cell topography-based mechanism for ligand discrimination by the T cell receptor.
Fernandes RA, Ganzinger KA, Tzou JC, Jönsson P, Lee SF, Palayret M, Santos AM, Carr AR, Ponjavic A, Chang VT, Macleod C, Lagerholm BC, Lindsay AE, Dushek O, Tilevik A, Davis SJ, Klenerman D. Fernandes RA, et al. Among authors: dushek o. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14002-14010. doi: 10.1073/pnas.1817255116. Epub 2019 Jun 20. Proc Natl Acad Sci U S A. 2019. PMID: 31221762 Free PMC article.
G6b-B antibody-based cis-acting platelet receptor inhibitors (CAPRIs) as a new family of anti-thrombotic therapeutics.
Mazharian A, Bertin O, Sarkar A, Augros J, Bornert A, Loubière C, Jönsson F, Warwicker J, Abbott WM, Dushek O, Vayne C, Rauova L, Fütterer K, Rollin J, Poncz M, Senis YA. Mazharian A, et al. Among authors: dushek o. bioRxiv [Preprint]. 2024 May 14:2024.05.10.593500. doi: 10.1101/2024.05.10.593500. bioRxiv. 2024. PMID: 38798354 Free PMC article. Preprint.
SpyAvidin hubs enable precise and ultrastable orthogonal nanoassembly.
Fairhead M, Veggiani G, Lever M, Yan J, Mesner D, Robinson CV, Dushek O, van der Merwe PA, Howarth M. Fairhead M, et al. Among authors: dushek o. J Am Chem Soc. 2014 Sep 3;136(35):12355-63. doi: 10.1021/ja505584f. Epub 2014 Aug 21. J Am Chem Soc. 2014. PMID: 25111182 Free PMC article.
T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles.
Céspedes PF, Jainarayanan A, Fernández-Messina L, Valvo S, Saliba DG, Kurz E, Kvalvaag A, Chen L, Ganskow C, Colin-York H, Fritzsche M, Peng Y, Dong T, Johnson E, Siller-Farfán JA, Dushek O, Sezgin E, Peacock B, Law A, Aubert D, Engledow S, Attar M, Hester S, Fischer R, Sánchez-Madrid F, Dustin ML. Céspedes PF, et al. Among authors: dushek o. Nat Commun. 2022 Jun 16;13(1):3460. doi: 10.1038/s41467-022-31160-3. Nat Commun. 2022. PMID: 35710644 Free PMC article.
68 results