El-Hamamsy MH - Search Results

1

Design and synthesis of quinazolin-4-one derivatives as potential anticancer agents and investigation of their interaction with RecQ helicases.

Haggag HS, Aboukhatwa SM, Nafie MS, Paul A, Sharafeldin N, Oliver AW, El-Hamamsy MH. Haggag HS, et al. Among authors: el hamamsy mh. Bioorg Chem. 2024 Mar;144:107086. doi: 10.1016/j.bioorg.2023.107086. Epub 2024 Jan 4. Bioorg Chem. 2024. PMID: 38219478

2

Synergy trap for guardian angels of DNA: Unraveling the anticancer potential of phthalazinone-thiosemicarbazone hybrids through dual PARP-1 and TOPO-I inhibition.

Elkafoury EM, El-Hamamsy MH, El-Bastawissy EA, Afarinkia K, Aboukhatwa SM. Elkafoury EM, et al. Among authors: el hamamsy mh. Bioorg Chem. 2024 Dec;153:107924. doi: 10.1016/j.bioorg.2024.107924. Epub 2024 Oct 29. Bioorg Chem. 2024. PMID: 39488147

3

Structure-based design, synthesis and preliminary evaluation of selective inhibitors of dihydrofolate reductase from Mycobacterium tuberculosis.

El-Hamamsy MH, Smith AW, Thompson AS, Threadgill MD. El-Hamamsy MH, et al. Bioorg Med Chem. 2007 Jul 1;15(13):4552-76. doi: 10.1016/j.bmc.2007.04.011. Epub 2007 Apr 10. Bioorg Med Chem. 2007. PMID: 17451962 Free article.

4

Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations.

Tawfik HO, Mousa MHA, Zaky MY, El-Dessouki AM, Sharaky M, Abdullah O, El-Hamamsy MH, Al-Karmalawy AA. Tawfik HO, et al. Among authors: el hamamsy mh. Bioorg Chem. 2024 Aug;149:107483. doi: 10.1016/j.bioorg.2024.107483. Epub 2024 May 21. Bioorg Chem. 2024. PMID: 38805913

5

Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents.

Khalil AF, El-Moselhy TF, El-Bastawissy EA, Abdelhady R, Younis NS, El-Hamamsy MH. Khalil AF, et al. Among authors: el hamamsy mh. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2157411. doi: 10.1080/14756366.2022.2157411. J Enzyme Inhib Med Chem. 2023. PMID: 36629449 Free PMC article.

6

Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR^WT, EGFR^T790M, and EGFR^L858R).

Abo Al-Hamd MG, Tawfik HO, Abdullah O, Yamaguchi K, Sugiura M, Mehany ABM, El-Hamamsy MH, El-Moselhy TF. Abo Al-Hamd MG, et al. Among authors: el hamamsy mh. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2241674. doi: 10.1080/14756366.2023.2241674. J Enzyme Inhib Med Chem. 2023. PMID: 37548154 Free PMC article.

7

The DPP-4 inhibitor sitagliptin improves glycaemic control and early-stage diabetic nephropathy in adolescents with type 1 diabetes using the MiniMed 780G advanced hybrid closed-loop system: a randomised controlled trial.

Elbarbary NS, Ismail EA, El-Hamamsy MH, Ibrahim MZ, Elkholy AA. Elbarbary NS, et al. Among authors: el hamamsy mh. Diabetologia. 2024 Dec;67(12):2637-2649. doi: 10.1007/s00125-024-06265-7. Epub 2024 Sep 14. Diabetologia. 2024. PMID: 39271520 Free PMC article. Clinical Trial.

8

Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents.

Tawfik HO, Belal A, Abourehab MAS, Angeli A, Bonardi A, Supuran CT, El-Hamamsy MH. Tawfik HO, et al. Among authors: el hamamsy mh. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2765-2785. doi: 10.1080/14756366.2022.2130285. J Enzyme Inhib Med Chem. 2022. PMID: 36210545 Free PMC article.

9

Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX.

Zain-Alabdeen AI, El-Moselhy TF, Sharafeldin N, Angeli A, Supuran CT, El-Hamamsy MH. Zain-Alabdeen AI, et al. Among authors: el hamamsy mh. Sci Rep. 2022 Oct 6;12(1):16756. doi: 10.1038/s41598-022-21024-7. Sci Rep. 2022. PMID: 36202955 Free PMC article.

10

Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies.

Saad MH, El-Moselhy TF, S El-Din N, Mehany ABM, Belal A, Abourehab MAS, Tawfik HO, El-Hamamsy MH. Saad MH, et al. Among authors: el hamamsy mh. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2489-2511. doi: 10.1080/14756366.2022.2120478. J Enzyme Inhib Med Chem. 2022. PMID: 36093880 Free PMC article.

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