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Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells.
Roy G, Ordóñez A, Binns DD, Rodrigues Dos Santos K, Kwakye MB, King GC, Mukherjee N, Templin AT, Tan Z, Richardson TI, Doud EH, Mosley AL, Emfinger CH, Attie AD, Keller MP, Johnson TS, Kalwat MA. Roy G, et al. Among authors: templin at. bioRxiv [Preprint]. 2024 Dec 26:2024.12.26.629558. doi: 10.1101/2024.12.26.629558. bioRxiv. 2024. PMID: 39763878 Free PMC article. Preprint.
The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity.
Esser N, Hogan MF, Templin AT, Akter R, Fountaine BS, Castillo JJ, El-Osta A, Manathunga L, Zhyvoloup A, Raleigh DP, Zraika S, Hull RL, Kahn SE. Esser N, et al. Among authors: templin at. Diabetologia. 2024 Sep;67(9):1897-1911. doi: 10.1007/s00125-024-06161-0. Epub 2024 Sep 9. Diabetologia. 2024. PMID: 39245780 Free PMC article.
Insulinotropic Effects of Neprilysin and/or Angiotensin Receptor Inhibition in Mice.
Esser N, Schmidt C, Barrow BM, Cronic L, Hackney DJ, Mongovin SM, Hogan MF, Templin AT, Castillo JJ, Hull RL, Zraika S. Esser N, et al. Among authors: templin at. Front Endocrinol (Lausanne). 2022 Jun 6;13:888867. doi: 10.3389/fendo.2022.888867. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 35733766 Free PMC article.
27 results