Hyle J - Search Results

1

RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9.

Zhang M, Hyle J, Chen X, Xin Y, Jin Y, Zhang J, Yang X, Chen X, Wright S, Liu Z, Rosikiewicz W, Xu B, He L, Liu H, Ping N, Wu D, Wen F, Li C, Xu P. Zhang M, et al. Among authors: hyle j. Genome Biol. 2024 Jan 12;25(1):16. doi: 10.1186/s13059-023-03149-8. Genome Biol. 2024. PMID: 38216972 Free PMC article.

2

Acute depletion of CTCF rewires genome-wide chromatin accessibility.

Xu B, Wang H, Wright S, Hyle J, Zhang Y, Shao Y, Niu M, Fan Y, Rosikiewicz W, Djekidel MN, Peng J, Lu R, Li C. Xu B, et al. Among authors: hyle j. Genome Biol. 2021 Aug 24;22(1):244. doi: 10.1186/s13059-021-02466-0. Genome Biol. 2021. PMID: 34429148 Free PMC article.

3

Auxin-inducible degron 2 system deciphers functions of CTCF domains in transcriptional regulation.

Hyle J, Djekidel MN, Williams J, Wright S, Shao Y, Xu B, Li C. Hyle J, et al. Genome Biol. 2023 Jan 26;24(1):14. doi: 10.1186/s13059-022-02843-3. Genome Biol. 2023. PMID: 36698211 Free PMC article.

4

Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens.

Wright S, Zhao X, Rosikiewicz W, Mryncza S, Hyle J, Qi W, Liu Z, Yi S, Cheng Y, Xu B, Li C. Wright S, et al. Among authors: hyle j. Nat Commun. 2023 Nov 28;14(1):7464. doi: 10.1038/s41467-023-43264-5. Nat Commun. 2023. PMID: 38016946 Free PMC article.

5

Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping.

Hyle J, Zhang Y, Wright S, Xu B, Shao Y, Easton J, Tian L, Feng R, Xu P, Li C. Hyle J, et al. Nucleic Acids Res. 2019 Jul 26;47(13):6699-6713. doi: 10.1093/nar/gkz462. Nucleic Acids Res. 2019. PMID: 31127282 Free PMC article.

6

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.

Zhang H, Zhang Y, Zhou X, Wright S, Hyle J, Zhao L, An J, Zhao X, Shao Y, Xu B, Lee HM, Chen T, Zhou Y, Chen X, Lu R, Li C. Zhang H, et al. Among authors: hyle j. Elife. 2020 Oct 1;9:e57858. doi: 10.7554/eLife.57858. Elife. 2020. PMID: 33001025 Free PMC article.

7

Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens.

Wright S, Hu J, Wang H, Hyle J, Zhang Y, Du G, Konopleva MY, Kornblau SM, Djekidel MN, Rosikiewicz W, Xu B, Lu R, Yang JJ, Li C. Wright S, et al. Among authors: hyle j. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2220134120. doi: 10.1073/pnas.2220134120. Epub 2023 Apr 10. Proc Natl Acad Sci U S A. 2023. PMID: 37036970 Free PMC article.

8

A cis-element within the ARF locus mediates repression of p16^INK4A expression via long-range chromatin interactions.

Zhang Y, Hyle J, Wright S, Shao Y, Zhao X, Zhang H, Li C. Zhang Y, et al. Among authors: hyle j. Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):26644-26652. doi: 10.1073/pnas.1909720116. Epub 2019 Dec 9. Proc Natl Acad Sci U S A. 2019. PMID: 31818950 Free PMC article.

9

Discovery of regulatory noncoding variants in individual cancer genomes by using cis-X.

Liu Y, Li C, Shen S, Chen X, Szlachta K, Edmonson MN, Shao Y, Ma X, Hyle J, Wright S, Ju B, Rusch MC, Liu Y, Li B, Macias M, Tian L, Easton J, Qian M, Yang JJ, Hu S, Look AT, Zhang J. Liu Y, et al. Among authors: hyle j. Nat Genet. 2020 Aug;52(8):811-818. doi: 10.1038/s41588-020-0659-5. Epub 2020 Jul 6. Nat Genet. 2020. PMID: 32632335 Free PMC article.

10

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.

Vo BT, Li C, Morgan MA, Theurillat I, Finkelstein D, Wright S, Hyle J, Smith SMC, Fan Y, Wang YD, Wu G, Orr BA, Northcott PA, Shilatifard A, Sherr CJ, Roussel MF. Vo BT, et al. Among authors: hyle j. Cell Rep. 2017 Mar 21;18(12):2907-2917. doi: 10.1016/j.celrep.2017.02.073. Cell Rep. 2017. PMID: 28329683 Free PMC article.

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