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Safety and virologic impact of the IL-15 superagonist N-803 in people living with HIV: a phase 1 trial.
Miller JS, Davis ZB, Helgeson E, Reilly C, Thorkelson A, Anderson J, Lima NS, Jorstad S, Hart GT, Lee JH, Safrit JT, Wong H, Cooley S, Gharu L, Chung H, Soon-Shiong P, Dobrowolski C, Fletcher CV, Karn J, Douek DC, Schacker TW. Miller JS, et al. Among authors: schacker tw. Nat Med. 2022 Feb;28(2):392-400. doi: 10.1038/s41591-021-01651-9. Epub 2022 Jan 31. Nat Med. 2022. PMID: 35102335 Clinical Trial.
Collagen deposition limits immune reconstitution in the gut.
Estes J, Baker JV, Brenchley JM, Khoruts A, Barthold JL, Bantle A, Reilly CS, Beilman GJ, George ME, Douek DC, Haase AT, Schacker TW. Estes J, et al. Among authors: schacker tw. J Infect Dis. 2008 Aug 15;198(4):456-64. doi: 10.1086/590112. J Infect Dis. 2008. PMID: 18598193 Free PMC article.
Lymphoid fibrosis occurs in long-term nonprogressors and persists with antiretroviral therapy but may be reversible with curative interventions.
Sanchez JL, Hunt PW, Reilly CS, Hatano H, Beilman GJ, Khoruts A, Jasurda JS, Somsouk M, Thorkelson A, Russ S, Anderson J, Deeks SG, Schacker TW. Sanchez JL, et al. Among authors: schacker tw. J Infect Dis. 2015 Apr 1;211(7):1068-75. doi: 10.1093/infdis/jiu586. Epub 2014 Oct 24. J Infect Dis. 2015. PMID: 25344521 Free PMC article.
Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.
Rothenberger MK, Keele BF, Wietgrefe SW, Fletcher CV, Beilman GJ, Chipman JG, Khoruts A, Estes JD, Anderson J, Callisto SP, Schmidt TE, Thorkelson A, Reilly C, Perkey K, Reimann TG, Utay NS, Nganou Makamdop K, Stevenson M, Douek DC, Haase AT, Schacker TW. Rothenberger MK, et al. Among authors: schacker tw. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1126-34. doi: 10.1073/pnas.1414926112. Epub 2015 Feb 23. Proc Natl Acad Sci U S A. 2015. PMID: 25713386 Free PMC article.
Impact of Integrase Inhibition Compared With Nonnucleoside Inhibition on HIV Reservoirs in Lymphoid Tissues.
Rothenberger M, Nganou-Makamdop K, Kityo C, Ssali F, Chipman JG, Beilman GJ, Hoskuldsson T, Anderson J, Jasurda J, Schmidt TE, Calisto SP, Pearson H, Reimann T, David C, Perkey K, Southern P, Wietgrefe S, Helgeson E, Reilly C, Haase AT, Douek DC, Fletcher CV, Schacker TW. Rothenberger M, et al. Among authors: schacker tw. J Acquir Immune Defic Syndr. 2019 Jul 1;81(3):355-360. doi: 10.1097/QAI.0000000000002026. J Acquir Immune Defic Syndr. 2019. PMID: 31192893 Free PMC article.
125 results