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SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes.
Shen Y, Stracquadanio G, Wang Y, Yang K, Mitchell LA, Xue Y, Cai Y, Chen T, Dymond JS, Kang K, Gong J, Zeng X, Zhang Y, Li Y, Feng Q, Xu X, Wang J, Wang J, Yang H, Boeke JD, Bader JS. Shen Y, et al. Genome Res. 2016 Jan;26(1):36-49. doi: 10.1101/gr.193433.115. Epub 2015 Nov 13. Genome Res. 2016. PMID: 26566658 Free PMC article.
Deep functional analysis of synII, a 770-kilobase synthetic yeast chromosome.
Shen Y, Wang Y, Chen T, Gao F, Gong J, Abramczyk D, Walker R, Zhao H, Chen S, Liu W, Luo Y, Müller CA, Paul-Dubois-Taine A, Alver B, Stracquadanio G, Mitchell LA, Luo Z, Fan Y, Zhou B, Wen B, Tan F, Wang Y, Zi J, Xie Z, Li B, Yang K, Richardson SM, Jiang H, French CE, Nieduszynski CA, Koszul R, Marston AL, Yuan Y, Wang J, Bader JS, Dai J, Boeke JD, Xu X, Cai Y, Yang H. Shen Y, et al. Science. 2017 Mar 10;355(6329):eaaf4791. doi: 10.1126/science.aaf4791. Science. 2017. PMID: 28280153 Free PMC article.
Systematical Engineering of Synthetic Yeast for Enhanced Production of Lycopene.
Zhang Y, Chiu TY, Zhang JT, Wang SJ, Wang SW, Liu LY, Ping Z, Wang Y, Chen A, Zhang WW, Chen T, Wang Y, Shen Y. Zhang Y, et al. Among authors: shen y. Bioengineering (Basel). 2021 Jan 19;8(1):14. doi: 10.3390/bioengineering8010014. Bioengineering (Basel). 2021. PMID: 33477926 Free PMC article.
A new era of mass data storage in artificial chromosome.
Ping Z, Yang H, Shen Y. Ping Z, et al. Among authors: shen y. Sci China Life Sci. 2022 Jul;65(7):1477-1478. doi: 10.1007/s11427-022-2073-3. Epub 2022 Mar 18. Sci China Life Sci. 2022. PMID: 35316457 No abstract available.
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