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Page 1
Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome.
Delafontaine S, Iannuzzo A, Bigley TM, Mylemans B, Rana R, Baatsen P, Poli MC, Rymen D, Jansen K, Mekahli D, Casteels I, Cassiman C, Demaerel P, Lepelley A, Frémond ML, Schrijvers R, Bossuyt X, Vints K, Huybrechts W, Tacine R, Willekens K, Corveleyn A, Boeckx B, Baggio M, Ehlers L, Munck S, Lambrechts D, Voet A, Moens L, Bucciol G, Cooper MA, Davis CM, Delon J, Meyts I. Delafontaine S, et al. Among authors: tacine r. J Clin Invest. 2024 Jan 4;134(4):e163604. doi: 10.1172/JCI163604. J Clin Invest. 2024. PMID: 38175705 Free PMC article.
cAMP Bursts Control T Cell Directionality by Actomyosin Cytoskeleton Remodeling.
Simao M, Régnier F, Taheraly S, Fraisse A, Tacine R, Fraudeau M, Benabid A, Feuillet V, Lambert M, Delon J, Randriamampita C. Simao M, et al. Among authors: tacine r. Front Cell Dev Biol. 2021 May 20;9:633099. doi: 10.3389/fcell.2021.633099. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34095108 Free PMC article.
A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome.
Bekhouche B, Tourville A, Ravichandran Y, Tacine R, Abrami L, Dussiot M, Khau-Dancasius A, Boccara O, Khirat M, Mangeney M, Dingli F, Loew D, Boëda B, Jordan P, Molina TJ, Bellon N, Fraitag S, Hadj-Rabia S, Blanche S, Puel A, Etienne-Manneville S, van der Goot FG, Cherfils J, Hermine O, Casanova JL, Bodemer C, Smahi A, Delon J. Bekhouche B, et al. Among authors: tacine r. J Allergy Clin Immunol. 2020 Nov;146(5):1201-1204.e8. doi: 10.1016/j.jaci.2020.03.020. Epub 2020 Apr 10. J Allergy Clin Immunol. 2020. PMID: 32283203 No abstract available.
Autoinflammatory patients with Golgi-trapped CDC42 exhibit intracellular trafficking defects leading to STING hyperactivation and ER stress.
Iannuzzo A, Delafontaine S, El Masri R, Tacine R, Prencipe G, Nishitani-Isa M, van Wijck RTA, Bhuyan F, de Jesus Rasheed AA, Coppola S, van Daele PLA, Insalaco A, Goldbach-Mansky R, Yasumi T, Tartaglia M, Meyts I, Delon J. Iannuzzo A, et al. Among authors: tacine r. Nat Commun. 2024 Nov 16;15(1):9940. doi: 10.1038/s41467-024-54294-y. Nat Commun. 2024. PMID: 39550374 Free PMC article.
FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction.
Roux A, Leroy H, De Muylder B, Bracq L, Oussous S, Dusanter-Fourt I, Chougui G, Tacine R, Randriamampita C, Desjardins D, Le Grand R, Bouillaud F, Benichou S, Margottin-Goguet F, Cheynier R, Bismuth G, Mangeney M. Roux A, et al. Among authors: tacine r. PLoS Pathog. 2019 May 1;15(5):e1007669. doi: 10.1371/journal.ppat.1007669. eCollection 2019 May. PLoS Pathog. 2019. PMID: 31042779 Free PMC article.