Oshida SI - Search Results

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Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.

Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: oshida si. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624

Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity.

Iida T, Ubukata M, Mitani I, Nakagawa Y, Maeda K, Imai H, Ogoshi Y, Hotta T, Sakata S, Sano R, Morinaga H, Negoro T, Oshida S, Tanaka M, Inaba T. Iida T, et al. Eur J Med Chem. 2018 Oct 5;158:832-852. doi: 10.1016/j.ejmech.2018.09.003. Eur J Med Chem. 2018. PMID: 30248655

JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity.

Okuma C, Ohta T, Tadaki H, Hamada H, Oda T, Taniuchi H, Yamanaka K, Ishii Y, Ohe Y, Yata S, Nishiu J, Aratsu Y, Oshida S, Kume S, Kakutani M. Okuma C, et al. Eur J Pharmacol. 2015 Jul 5;758:72-81. doi: 10.1016/j.ejphar.2015.03.072. Epub 2015 Apr 6. Eur J Pharmacol. 2015. PMID: 25857225

Selenium and Glutathione-Depleted Rats as a Sensitive Animal Model to Predict Drug-Induced Liver Injury in Humans.

Goda K, Muta K, Yasui Y, Oshida S, Kitatani K, Takekoshi S. Goda K, et al. Int J Mol Sci. 2019 Jun 27;20(13):3141. doi: 10.3390/ijms20133141. Int J Mol Sci. 2019. PMID: 31252607 Free PMC article.

Relationships between plasma and tissue transaminase activities in rats maintained under different feeding conditions.

Kobayashi A, Oshida S, Yamazaki Y, Maekawa T, Kuno H, Sugai S, Sakakibara H, Shimoi K. Kobayashi A, et al. J Toxicol Sci. 2010 Oct;35(5):639-52. doi: 10.2131/jts.35.639. J Toxicol Sci. 2010. PMID: 20930459 Free article.

A pharmacologic increase in activity of plasma transaminase derived from small intestine in animals receiving an acyl CoA: diacylglycerol transferase (DGAT) 1 inhibitor.

Yokoyama H, Kobayashi A, Kondo K, Oshida SI, Takahashi T, Masuyama T, Shoda T, Sugai S. Yokoyama H, et al. Among authors: oshida si. J Toxicol Sci. 2018;43(2):135-157. doi: 10.2131/jts.43.135. J Toxicol Sci. 2018. PMID: 29479035 Free article.

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