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Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: hara y. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624
Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety.
Hirashima S, Oka T, Ikegashira K, Noji S, Yamanaka H, Hara Y, Goto H, Mizojiri R, Niwa Y, Noguchi T, Ando I, Ikeda S, Hashimoto H. Hirashima S, et al. Among authors: hara y. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3181-6. doi: 10.1016/j.bmcl.2007.03.027. Epub 2007 Mar 14. Bioorg Med Chem Lett. 2007. PMID: 17383878
Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.
Noji S, Hara Y, Miura T, Yamanaka H, Maeda K, Hori A, Yamamoto H, Obika S, Inoue M, Hase Y, Orita T, Doi S, Adachi T, Tanimoto A, Oki C, Kimoto Y, Ogawa Y, Negoro T, Hashimoto H, Shiozaki M. Noji S, et al. Among authors: hara y. J Med Chem. 2020 Jul 9;63(13):7163-7185. doi: 10.1021/acs.jmedchem.0c00450. Epub 2020 Jun 29. J Med Chem. 2020. PMID: 32511913
Correction to "Optimization Efforts for Identification of Novel Highly Potent Keap1-Nrf2 Protein-Protein Interaction Inhibitors".
Otake K, Hara Y, Ubukata M, Inoue M, Nagahashi N, Motoda D, Ogawa N, Hantani Y, Hantani R, Adachi T, Nomura A, Yamaguchi K, Maekawa M, Mamada H, Motomura T, Sato M, Harada K. Otake K, et al. Among authors: hara y. J Med Chem. 2024 Sep 12;67(17):15925. doi: 10.1021/acs.jmedchem.4c01985. Epub 2024 Sep 2. J Med Chem. 2024. PMID: 39219436 No abstract available.
Three-Dimensional Sectional Measurements of Shoulder Muscle Volume and Computed Tomography Density to Monitor Serial Postoperative Volume Changes in the Transverse Force Couple of Shoulder Muscles in Anterior Shoulder Instability.
Nagawa K, Hara Y, Kakemoto S, Shiratori T, Kaizu A, Koyama M, Inoue K, Sakaguchi K, Kozawa E. Nagawa K, et al. Among authors: hara y. Cureus. 2024 Dec 2;16(12):e74963. doi: 10.7759/cureus.74963. eCollection 2024 Dec. Cureus. 2024. PMID: 39744284 Free PMC article.
2,865 results