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Amyloid-induced β-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment.
Montane J, de Pablo S, Castaño C, Rodríguez-Comas J, Cadavez L, Obach M, Visa M, Alcarraz-Vizán G, Sanchez-Martinez M, Nonell-Canals A, Parrizas M, Servitja JM, Novials A. Montane J, et al. Among authors: cadavez l. FASEB J. 2017 Dec;31(12):5296-5306. doi: 10.1096/fj.201700236R. Epub 2017 Aug 15. FASEB J. 2017. PMID: 28821639 Free PMC article.
BACE2 plays a role in the insulin receptor trafficking in pancreatic ß-cells.
Casas S, Casini P, Piquer S, Altirriba J, Soty M, Cadavez L, Gomis R, Novials A. Casas S, et al. Among authors: cadavez l. Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1087-95. doi: 10.1152/ajpendo.00420.2010. Epub 2010 Oct 13. Am J Physiol Endocrinol Metab. 2010. PMID: 20943756 Free article.