Simon MC - Search Results

1

Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer.

Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, Li J, Zhu L, Keith B, Simon MC. Li F, et al. Among authors: simon mc. Nat Cancer. 2024 Jan;5(1):131-146. doi: 10.1038/s43018-023-00671-3. Epub 2024 Jan 2. Nat Cancer. 2024. PMID: 38168934 Free PMC article.

2

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt.

Keith B, Adelman DM, Simon MC. Keith B, et al. Among authors: simon mc. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6692-7. doi: 10.1073/pnas.121494298. Epub 2001 May 29. Proc Natl Acad Sci U S A. 2001. PMID: 11381139 Free PMC article.

3

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.

Mack FA, Rathmell WK, Arsham AM, Gnarra J, Keith B, Simon MC. Mack FA, et al. Among authors: simon mc. Cancer Cell. 2003 Jan;3(1):75-88. doi: 10.1016/s1535-6108(02)00240-4. Cancer Cell. 2003. PMID: 12559177 Free PMC article.

4

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.

Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Hu CJ, et al. Among authors: simon mc. Mol Cell Biol. 2003 Dec;23(24):9361-74. doi: 10.1128/MCB.23.24.9361-9374.2003. Mol Cell Biol. 2003. PMID: 14645546 Free PMC article.

5

Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species.

Mansfield KD, Simon MC, Keith B. Mansfield KD, et al. Among authors: simon mc. J Appl Physiol (1985). 2004 Oct;97(4):1358-66. doi: 10.1152/japplphysiol.00449.2004. Epub 2004 Jun 4. J Appl Physiol (1985). 2004. PMID: 15180977 Free article.

6

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.

Covello KL, Simon MC, Keith B. Covello KL, et al. Among authors: simon mc. Cancer Res. 2005 Mar 15;65(6):2277-86. doi: 10.1158/0008-5472.CAN-04-3246. Cancer Res. 2005. PMID: 15781641

7

Hypoxia-induced energy stress regulates mRNA translation and cell growth.

Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. Liu L, et al. Among authors: simon mc. Mol Cell. 2006 Feb 17;21(4):521-31. doi: 10.1016/j.molcel.2006.01.010. Mol Cell. 2006. PMID: 16483933 Free PMC article.

8

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B. Covello KL, et al. Among authors: simon mc. Genes Dev. 2006 Mar 1;20(5):557-70. doi: 10.1101/gad.1399906. Genes Dev. 2006. PMID: 16510872 Free PMC article.

9

Acute postnatal ablation of Hif-2alpha results in anemia.

Gruber M, Hu CJ, Johnson RS, Brown EJ, Keith B, Simon MC. Gruber M, et al. Among authors: simon mc. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2301-6. doi: 10.1073/pnas.0608382104. Epub 2007 Feb 6. Proc Natl Acad Sci U S A. 2007. PMID: 17284606 Free PMC article.

10

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.

Rankin EB, Biju MP, Liu Q, Unger TL, Rha J, Johnson RS, Simon MC, Keith B, Haase VH. Rankin EB, et al. Among authors: simon mc. J Clin Invest. 2007 Apr;117(4):1068-77. doi: 10.1172/JCI30117. J Clin Invest. 2007. PMID: 17404621 Free PMC article.

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